Liver immunology: Biological role and clinical significance

doi:10.4254/wjh.v17.i7.107541

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Jul 27, 2025 (publication date) through Jul 28, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2025; 17(7): 107541
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107541

Liver immunology: Biological role and clinical significance

Stanislav Nikolaevich Kotlyarov

Stanislav Nikolaevich Kotlyarov, Department of Nurse, Ryazan State Medical University, Ryazan 390005, Russia

Author contributions: Kotlyarov SN contributed to the conceptualization, methodology, validation, resources, data curation, preparation of the original draft, review and editing, supervision, and project administration.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Stanislav Nikolaevich Kotlyarov, PhD, Professor, Department of Nurse, Ryazan State Medical University, 9 Vysokovoltnaya, Ryazan 390005, Russia. skmr1@yandex.ru

Received: March 26, 2025
Revised: May 5, 2025
Accepted: June 27, 2025
Published online: July 27, 2025
Processing time: 122 Days and 3.6 Hours

Core Tip

Core Tip: The liver is an important organ at the intersection of many metabolic and immune pathways. Immune cells in the liver have a complex regulation that can be impaired in various diseases such as metabolic dysfunction-associated steatotic liver disease, liver cancer, and biliary disorders. Interactions with the gut microbiota play an important role in liver immunology. Effects on immune mechanisms are considered a promising therapeutic target for liver diseases.