Opinion Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2025; 17(7): 107378
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107378
Liver regeneration after partial hepatectomy: Triggers and mechanisms
Bakari Korchilava, Tamar Khachidze, Nino Megrelishvili, Lika Svanadze, Manana Kakabadze, Keti Tsomaia, Memed Jintcharadze, Dimitri Kordzaia
Bakari Korchilava, Department of Clinical Anatomy and Operative Surgery, Ivane Javakhishvili Tbilisi State University, Tbilisi 0159, Georgia
Tamar Khachidze, Department of Clinical Anatomy, Tbilisi State Medical University, Tbilisi 0130, Georgia
Nino Megrelishvili, Department of Pathology, Ivane Javakhishvili Tbilisi State University, Tbilisi 0159, Georgia
Lika Svanadze, Manana Kakabadze, Keti Tsomaia, Dimitri Kordzaia, Alexandre Natishvili Institute of Morphology, Ivane Javakhishvili Tbilisi State University, Tbilisi 0159, Georgia
Memed Jintcharadze, Department of Oncosurgery, Batumi High-Tech Hospital, Medical Center, Batumi 6000, Ajaria, Georgia
Author contributions: Korchilava B, Gvidiani S, Jintcharadze M and Kordzaia D contributed substantially to the review article's conception and design; Drafting the article or providing critical revisions related to the important intellectual content of the manuscript was carried out by Korchilava B, Gvidiani S, Megrelishvili N, Svanadze L, Kakabadze M, Tsomaia K, Khachidze T, and Kordzaia D; Responses to the reviewers were prepared by Kordzaia D, Svanadze L, Korchilava B and Khachidze T and the final version was discussed and approved by all authors; Provision of final approval for the version of the article to be published was provided by Korchilava B, Gvidiani S, Svanadze L, Tsomaia K and Kordzaia D; All authors have made significant contributions to this paper and have approved.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dimitri Kordzaia, MD, PhD, Professor, Alexandre Natishvili Institute of Morphology, Ivane Javakhishvili Tbilisi State University, Beliashvili Street 78, Tbilisi 0159, Georgia. dimitri.kordzaia@tsu.ge
Received: March 26, 2025
Revised: April 23, 2025
Accepted: June 10, 2025
Published online: July 27, 2025
Processing time: 121 Days and 18.1 Hours
Core Tip

Core Tip: This review synthesizes key triggers and molecular pathways of Liver regeneration after partial hepatectomy, emphasizing the central role of portal hemodynamics, cytokine signaling, and extracellular matrix remodeling. It highlights underexplored processes such as ductular reaction in granulation tissue, and the role of metabolic regulators like bile acids and glutamine. The paper outlines mechanisms of the termination of liver regenerative and proposes new perspectives for its therapeutic modulation in clinical settings.