Li J, Wang W. Challenges of Klebsiella pneumoniae infections post-liver transplantation: Insights and future directions. World J Hepatol 2025; 17(7): 107213 [DOI: 10.4254/wjh.v17.i7.107213]
Corresponding Author of This Article
Wei Wang, MD, Associate Professor, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, No. 381-1 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. westernfox000@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 27, 2025; 17(7): 107213 Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107213
Challenges of Klebsiella pneumoniae infections post-liver transplantation: Insights and future directions
Jian Li, Wei Wang
Jian Li, Wei Wang, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, Taizhou 318000, Zhejiang Province, China
Author contributions: Li J methodology and formal analysis; Wang W conceptualization, writing, reviewing and editing; All authors participated in drafting the manuscript and all have read, contributed to, and approved the final version of the manuscript.
Supported by the Second Batch of Social Development Science and Technology Program Projects of Taizhou Science and Technology Bureau in 2023, No. 24ywb80.
Conflict-of-interest statement: Every author has stated that there is no commercial, professional, or personal conflict of interest relevant to the study, proving that it complies with the principles of publishing ethics.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, MD, Associate Professor, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, No. 381-1 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. westernfox000@163.com
Received: March 18, 2025 Revised: April 13, 2025 Accepted: June 25, 2025 Published online: July 27, 2025 Processing time: 129 Days and 21 Hours
Core Tip
Core Tip: Klebsiella pneumoniae infections are a major challenge in liver transplantation recipients, particularly due to carbapenem-resistant strains. Effective management requires addressing key risk factors, including pre-transplant colonization and immune dysregulation. Advanced diagnostics like genomic profiling and resistome analysis can enhance understanding of resistance and virulence mechanisms. Optimizing treatment regimens, such as polymyxin B and ceftazidime/avibactam, and developing novel therapeutics targeting specific resistance mechanisms are critical. Routine surveillance and international collaboration can further improve infection control strategies, ensuring better outcomes for this vulnerable population. Integrating microbiology, immunology, and pharmacology advances is essential for transforming liver transplantation infection care.
