Deciphering the role of taurine-upregulated gene 1 in liver diseases: Mechanisms, clinical relevance, and emerging therapeutic opportunities

doi:10.4254/wjh.v17.i7.106795

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Jul 27, 2025 (publication date) through Jul 25, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2025; 17(7): 106795
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.106795

Deciphering the role of taurine-upregulated gene 1 in liver diseases: Mechanisms, clinical relevance, and emerging therapeutic opportunities

Thammachanok Boonto, Chaiyaboot Ariyachet

Thammachanok Boonto, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Krung Thep Maha Nakhon, Thailand

Chaiyaboot Ariyachet, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Krung Thep Maha Nakhon, Thailand

Author contributions: Boonto T conducted the literature search, organized the structure of the review, and drafted the initial manuscript; Ariyachet C conceptualized the review and provided significant revisions to the manuscript; both authors edited and approved the final version of the manuscript.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Chaiyaboot Ariyachet, PhD, Assistant Professor, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Paettayaphat Building, Rama IV Road, Phatumwan, Bangkok 10330, Krung Thep Maha Nakhon, Thailand. chaiyaboot.a@chula.ac.th

Received: March 7, 2025
Revised: April 19, 2025
Accepted: June 18, 2025
Published online: July 27, 2025
Processing time: 140 Days and 12.7 Hours

Core Tip

Core Tip: Taurine-upregulated gene 1 (TUG1), a long noncoding RNA, plays a critical role in liver pathogenesis by regulating gene expression through diverse mechanisms, including acting as a microRNA sponge, interacting with proteins, and modulating signaling pathways. TUG1 is involved in various liver diseases, including hepatocellular carcinoma, liver injury, fibrosis/cirrhosis, and metabolic dysfunction–associated steatotic liver disease, making it a potential therapeutic target.