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World J Hepatol. Jul 27, 2025; 17(7): 103179
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.103179
Liver and systemic hemodynamics in cirrhotic children
Roberto Tambucci, Xavier Stephenne, Aniss Channaoui, Catherine de Magnée
Roberto Tambucci, Aniss Channaoui, Catherine de Magnée, Pediatric Surgery and Transplantation Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels 1200, Belgium
Xavier Stephenne, Pediatric Gastroenterology and Hepatology Division, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels 1200, Belgium
Author contributions: Tambucci R and de Magnée C conceptualized and designed the study, conducted the literature review, performed analysis, interpreted data, and drafted the original version of the manuscript; Stephenne X and Channaoui A conducted the literature review and made critical revisions; all authors prepared the draft and approved the submitted version.
Conflict-of-interest statement: None of the authors have a conflict of interest related to the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Catherine de Magnée, MD, PhD, Pediatric Surgery and Transplantation Unit, Cliniques Universitaires Saint-Luc, UCLouvain, 10 Hippocrate Avenue, Brussels 1200, Belgium. catherine.demagnee@saintluc.uclouvain.be
Received: November 11, 2024
Revised: April 12, 2025
Accepted: June 7, 2025
Published online: July 27, 2025
Processing time: 256 Days and 10.9 Hours
Core Tip

Core Tip: Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in adults. With the progression of cirrhosis, the circulation becomes hyperdynamic, with cardiac, pulmonary and renal consequences. Cirrhotic adults also present with cirrhotic cardiomyopathy. This article provides a brief review of liver and systemic hemodynamics in cirrhotic adults and a detailed description of liver and systemic hemodynamics in cirrhotic children. The characterization of these hemodynamic disturbances could contribute to a better understanding of hepatic and systemic physiopathology in pediatric cirrhosis, elements that should be included in the management of cirrhotic children.