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World J Hepatol. Apr 27, 2025; 17(4): 102978
Published online Apr 27, 2025. doi: 10.4254/wjh.v17.i4.102978
Psoriasis, metabolic syndrome and methotrexate: Is this association suitable for a new subcategory in steatotic liver disease?
Luciana Agoglia, Maria Chiara Chindamo, Cristiane Villela-Nogueira
Luciana Agoglia, Department of Internal Medicine, School of Medicine, Section of Gastroenterology, Hospital Universitário Antônio Pedro, Federal University Fluminense, Niterói 24033-900, Rio de Janeiro, Brazil
Maria Chiara Chindamo, Cristiane Villela-Nogueira, Department of Internal Medicine, School of Medicine and Hepatology Division, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil
Co-first authors: Luciana Agoglia and Maria Chiara Chindamo.
Author contributions: Agoglia L and Chindamo MC contributed equally as co-first authors; Agoglia L performed a critical literature review, prepared the manuscript, and wrote it; Chindamo MC and Villela-Nogueira C provided input in writing the paper and performed a critical review of the manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cristiane Villela-Nogueira, MD, PhD, Professor, Department of Internal Medicine, School of Medicine and Hepatology Division, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco 255 room 9E16, Rio de Janeiro 21941-913, Brazil. crisvillela@hucff.ufrj.br
Received: November 5, 2024
Revised: March 8, 2025
Accepted: March 27, 2025
Published online: April 27, 2025
Processing time: 172 Days and 11.3 Hours
Core Tip

Core Tip: The prevalence of metabolic syndrome and steatosis is higher in patients with psoriasis; the concept of the hepato-dermal axis shows common inflammatory pathways between steatotic liver and psoriatic skin. The interplay between metabolic dysfunction and the use of methotrexate in patients with psoriasis might raise questions about whether a new subcategory under the umbrella of steatotic liver disease might be considered.