Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2025; 17(3): 103835
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103835
Role of autoimmune phenomena in nonalcoholic fatty liver disease: Insights and limitations
Arunkumar Krishnan, Diptasree Mukherjee
Arunkumar Krishnan, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27101, United States
Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States
Diptasree Mukherjee, Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India
Co-first authors: Arunkumar Krishnan and Diptasree Mukherjee.
Author contributions: Krishnan A contributed to the concept of the study; Mukherjee D and Krishnan A were involved in critically revising the manuscript for important intellectual content, drafting the manuscript, and participating in the review and editing, they contributed equally to this article, they are the co-first authors of this manuscript; and all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arunkumar Krishnan, MD, Assistant Professor, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Received: December 2, 2024
Revised: February 21, 2025
Accepted: March 5, 2025
Published online: March 27, 2025
Processing time: 114 Days and 6.5 Hours
Core Tip

Core Tip: A study by Zhu et al investigated the presence of autoantibodies across different histological stages of nonalcoholic fatty liver disease (NAFLD). The findings suggest that autoantibodies may play a role in the immune dysregulation observed in NAFLD. We recommend further refinement by incorporating prospective methods and controlling for additional confounding factors such as body mass index and metabolic comorbidities. Expanding the antibody panel and measuring antibody titers with greater granularity could enhance the accuracy. Moreover, stratifying data by age and sex and exploring cytokine profiles may provide a better understanding of the immunological mechanisms involved in NAFLD progression.