Scientometrics
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2025; 17(3): 103327
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103327
Immune cells in metabolic associated fatty liver disease: Global trends and hotspots (2004-2024)
Wen-Ying Qi, Shi-Hao Zheng, Si-Ze Li, Wei Wang, Qiu-Yue Wang, Qi-Yao Liu, Xiao-Ke Li, Jia-Xin Zhang, Da-Nan Gan, Yong-An Ye, Xiao-Bin Zao
Wen-Ying Qi, Shi-Hao Zheng, Si-Ze Li, Wei Wang, Qiu-Yue Wang, Qi-Yao Liu, Xiao-Ke Li, Jia-Xin Zhang, Da-Nan Gan, Yong-An Ye, Xiao-Bin Zao, Department of Spleen and Stomach Diseases, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
Qi-Yao Liu, Xiao-Ke Li, Jia-Xin Zhang, Da-Nan Gan, Yong-An Ye, Xiao-Bin Zao, Institute of Hepatology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
Qi-Yao Liu, Xiao-Bin Zao, Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
Co-first authors: Wen-Ying Qi and Shi-Hao Zheng.
Co-corresponding authors: Yong-An Ye and Xiao-Bin Zao.
Author contributions: Qi WY and Zheng SH participated in data processing and statistical analysis, they contributed equally to this article, they are the co-first authors of this manuscript; Qi WY, Zheng SH, Li SZ, and Wang W drafted the manuscript; Wang QY, Liu QY, Li XK, Zhang JX, and Gan DN contributed to data analysis and interpretation; Qi WY, Zheng SH, Zao XB, and Ye YA supervised the review of the study; Zao XB and Ye YA conceived and designed the study, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors seriously revised and approved the final manuscript.
Supported by Horizontal Project of Dongzhimen Hospital, No. HX-DZM-202343.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bin Zao, Department of Spleen and Stomach Diseases, Dong-zhimen Hospital of Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. a3417@bucm.edu.cn
Received: November 18, 2024
Revised: February 7, 2025
Accepted: March 5, 2025
Published online: March 27, 2025
Processing time: 131 Days and 3 Hours
Core Tip

Core Tip: This study provides a comprehensive bibliometric analysis of global trends and hotspots in research on immune cells and metabolic associated fatty liver disease from 2004 to 2024. It highlights key proteins (e.g., interleukin-6, tumor necrosis factor, signal transducer and activator of transcription 3) and potential therapeutic targets identified through bioinformatics, emphasizing the critical roles of oxidative stress, metabolic syndrome, and Kupffer cells in metabolic associated fatty liver disease pathogenesis. The findings offer a roadmap for future research and clinical strategies to address this growing health challenge.