Retrospective Study
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World J Hepatol. Feb 27, 2025; 17(2): 99134
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.99134
Survival of patients with hepatopulmonary syndrome related to cirrhotic and non-cirrhotic (schistosomiasis) portal hypertension
Melissa M Rolim, Liana G Farsoun, Carlos F Luna, Brivaldo Markman-Filho, Paulo Querette, Edmundo P Lopes, Ana L Domingues
Melissa M Rolim, Edmundo P Lopes, Ana L Domingues, Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco, Recife 50670901, Pernambuco, Brazil
Liana G Farsoun, Faculdade de Medicina UniNassau, Grupo Ser Educacional, Recife 50100220, Pernambuco, Brazil
Carlos F Luna, Statistics and Geoprocessing Center, Institute Aggeu Magalhães, Oswaldo Cruz Foundation, Recife 50740465, Pernambuco, Brazil
Brivaldo Markman-Filho, Department of Cardiology Division, Hospital das Clínicas/EBSERH-Universidade Federal de Pernambuco, Recife 50670901, Pernambuco, Brazil
Brivaldo Markman-Filho, Edmundo P Lopes, Ana L Domingues, Department of Internal Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco, Recife 50670901, Pernambuco, Brazil
Paulo Querette, Postgraduate Program in Translational Health, Center of Medical Sciences, Universidade Federal de Pernambuco, Recife 50670901, Pernambuco, Brazil
Edmundo P Lopes, Ana L Domingues, Department of Gastroenterology Division, Hospital das Clínicas/EBSERH-Universidade Federal de Pernambuco, Recife 50670901, Pernambuco, Brazil
Co-corresponding authors: Melissa M Rolim and Edmundo P Lopes.
Author contributions: Rolim MM, Farsoun LG, Markman-Filho B, Lopes EP, and Domingues AL participated in the conception and design of the study; Rolim MM and Lopes EP contributed equally to this article, they are the co-first authors of this manuscript; Rolim MM, Querette P, Lopes EP, and Domingues AL were involved in the acquisition of the data; Farsoun LG and Luna CF was involved in the analysis of the data; Rolim MM, Farsoun LG, Luna CF, Markman-Filho B, Querette P, Lopes EP, and Domingues AL were involved in the interpretation of the data and made substantial contributions to conception of the study; and all authors made critical revisions of the manuscript and had final approval of the version of the article to be published.
Institutional review board statement: This study was approved by the Research Ethics Committee of the Health Sciences Center of the Universidade Federal de Pernambuco (CAAE 66964822.6.0000.5208, No. 5.968.435) on March 28, 2023.
Informed consent statement: This study had no Informed consent statement because our data were from a secondary basis. Furthermore, the study was approved by the government department responsible for deaths records.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: This study had no data sharing statement because our data were from a secondary basis, and the present data of the study are anonymized, with a very low risk of identification.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Melissa M Rolim, MD, Postgraduate Program in Tropical Medicine, Center of Medical Sciences, 1235 Professor Moraes Rego Avenue, Recife 50670901, Pernambuco, Brazil. melissarolim.mr@gmail.com
Received: July 14, 2024
Revised: December 19, 2024
Accepted: December 25, 2024
Published online: February 27, 2025
Processing time: 220 Days and 10.5 Hours
Core Tip

Core Tip: Hepatopulmonary syndrome (HPS) increases the risk of mortality in patients with cirrhosis, but there is no data on the mortality of patients with hepatosplenic schistosomiasis. This study performed a survival analysis of patients with HPS related to cirrhotic and non-cirrhotic (schistosomiasis) portal hypertension. Patients who participated in a cross-sectional study on HPS 10 years ago were included, and survival analysis was performed using the Kaplan-Meier method. Our results showed that patients with hepatosplenic schistosomiasis and concomitant cirrhosis had lower survival compared with those without cirrhosis, but there was no difference in survival regardless of the presence of HPS.