Gilbert’s syndrome: The good, the bad and the ugly

doi:10.4254/wjh.v17.i2.98503

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Feb 27, 2025 (publication date) through Feb 20, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Feb 27, 2025; 17(2): 98503
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.98503

Gilbert’s syndrome: The good, the bad and the ugly

Arjuna Priyadarsin De Silva, Nilushi Nuwanshika, Madunil Anuk Niriella, Hithanadura Janaka de Silva

Arjuna Priyadarsin De Silva, Nilushi Nuwanshika, Madunil Anuk Niriella, Hithanadura Janaka de Silva, Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka

Co-corresponding authors: Arjuna Priyadarsin De Silva and Nilushi Nuwanshika.

Author contributions: De Silva AP and Nuwanshika N wrote the original draft, they contributed equally as co-corresponding authors; Niriella MA and de Silva HJ investigated and reviewed the manuscript; and all authors read and approved the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Arjuna Priyadarsin De Silva, MD, Department of Medicine, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Sri Lanka. apdsilva@yahoo.com

Received: June 27, 2024
Revised: November 14, 2024
Accepted: December 20, 2024
Published online: February 27, 2025
Processing time: 237 Days and 14.6 Hours

Core Tip

Core Tip: Gilbert’s syndrome is a benign hereditary disorder characterized by mild hyperbilirubinemia. This comprehensive review delves into the genetic and environmental determinants of Gilbert’s syndrome, elucidating its possible protective role against cardiovascular diseases, metabolic disorders, and certain malignancies, attributed to the antioxidant properties of bilirubin. Additionally, it addresses potential complications during pregnancy and the neonatal period, alongside a possible association with severe schizophrenia. Emphasis is placed on the importance of early diagnosis and patient education to mitigate unnecessary medical interventions and optimize clinical outcomes.