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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2025; 17(2): 101914
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101914
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101914
Overexpression and clinicopathological significance of zinc finger protein 71 in hepatocellular carcinoma
Kai Qin, Dan-Dan Xiong, Zhen Qin, Qi Li, Zhi-Guang Huang, Yu-Xing Tang, Jian-Di Li, Yan-Ting Zhan, Jie Luo, Hai-Quan Wang, Shu-Qi Zhang, Gang Chen, Dan-Ming Wei, Yi-Wu Dang, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Ming-Jie Li, Department of Pathology/Forensic Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Rong-Quan He, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Co-first authors: Kai Qin and Dan-Dan Xiong.
Co-corresponding authors: Dan-Ming Wei and Yi-Wu Dang.
Author contributions: Qin K, Xiong DD, Wei DM, and Dang YW conceived and designed the study; Qin Z, Li MJ, Li Q, Huang ZG, Tang YX, Li JD, and Chen G analyzed the data and created all of the graphs; Zhan YT, He RQ, Luo J, Wang HQ, and Zhang SQ provided technical support and experimental materials; Qin K and Xiong DD drafted the manuscript, and contributed equally as co-first authors; Wei DM and Dang YW revised the manuscript, and contributed equally as co-corresponding authors.
Supported by Joint Project on Regional High Incidence Diseases Research of Guangxi Natural Science Foundation, No. 2024GXNSFAA010057 and No. 2024GXNSFAA010085; Natural Science Foundation of Guangxi, China, No. 2022GXNSFBA035657; Guangxi Zhuang Autonomous Region Health Commission Self-Financed Scientific Research Project, No. Z20210764; Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project, No. GXZYA20230270 and No. GXZYA20240305; and Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University (2022).
Institutional review board statement: The protocol for this research project has been approved by a suitably constituted Ethics Committee of the institution Committee of Pantomics, Inc. (Approval No. Fanpu [2018] 23).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data are available from the corresponding author at dangyiwu@gxmu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Wu Dang, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. dangyiwu@gxmu.edu.cn
Received: October 8, 2024
Revised: December 22, 2024
Accepted: January 18, 2025
Published online: February 27, 2025
Processing time: 142 Days and 13.1 Hours
Revised: December 22, 2024
Accepted: January 18, 2025
Published online: February 27, 2025
Processing time: 142 Days and 13.1 Hours
Core Tip
Core Tip: This study identified zinc finger protein 71 (ZNF71) as a key marker significantly upregulated in hepatocellular carcinoma (HCC), linking its elevated levels to increased disease severity. Employing a comprehensive methodology, including immunohistochemistry, high-throughput analysis, and single-cell sequencing, we demonstrated the involvement of ZNF71 in promoting HCC progression through cell cycle and metabolic pathways. Our findings underscore the potential of ZNF71 as a therapeutic target, especially given its association with immune cell infiltration, highlighting its role in the tumor microenvironment.