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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2025; 17(2): 101741
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101741
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101741
Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver
Ying Zhao, Yu-Jin Zhu, Yan Zhang, Wen-Wen Zheng, Lin Ma, Graduate School, Tianjin Medical University, Tianjin 300070, China
Jian-Zhou Li, Diagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People’s Hospital, Xining 810003, Qinghai Province, China
Yong-Gang Liu, Department of Pathology, Tianjin Second People's Hospital, Tianjin 300110, China
Jia Li, Chun-Yan Wang, Department of Gastroenterology, Tianjin Second People's Hospital, Tianjin 300110, China
Author contributions: Zhao Y wrote the manuscript; Zhu YJ, Zhang Y, Zheng WW, and ML contributed to data collation; Zhang Y and Li J contributed to statistical analysis; Liu YG contributed to liver pathology reading; Li JZ, Wang CY, and Li J contributed to manuscript revision; Wang CY and Li J contributed to research supervision; Wang CY contributed to project design.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Tianjin Second People’s Hospital.
Informed consent statement: Patients were not required to provide informed consent for the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment via written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yan Wang, MD, Department of Gastroenterology, Tianjin Second People's Hospital, No. 7 Sudi South Road, Nankai District, Tianjin 300110, China.
Received: September 25, 2024
Revised: November 28, 2024
Accepted: December 25, 2024
Published online: February 27, 2025
Processing time: 148 Days and 6.7 Hours
Revised: November 28, 2024
Accepted: December 25, 2024
Published online: February 27, 2025
Processing time: 148 Days and 6.7 Hours
Core Tip
Core Tip: In this retrospective study, we explored the clinical features and prognosis of patients with drug-induced liver injury (DILI) in the setting of nonalcoholic fatty liver (NAFL). We recruited a total of 199 patients diagnosed with DILI by clinical and biochemical indicators. The number of patients diagnosed with NAFL by pathologic biopsy, ultrasound, and computed tomography was 110, and the number of patients without NAFL was 89. DILI resulting from NAFL had more pronounced metabolic index abnormalities, was more prone to cholestasis, had a greater degree of hepatic injury, had a longer recovery time, and may involve more pronounced immunologic factors.