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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2025; 17(2): 101165
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101165
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101165
Sarcopenia and metabolic dysfunction-associated steatotic liver disease: The role of exercise-related biomarkers
Marwan S Al-Nimer, Department of Therapeutics and Clinical Pharmacology, College of Medicine, University of Diyala, Baqubah 32001, Iraq
Author contributions: Al-Nimer MS contributed to conception, design, writing, and editing.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marwan S Al-Nimer, MD, PhD, Department of Therapeutics and Clinical Pharmacology, College of Medicine, University of Diyala, University Street, Baqubah 32001, Iraq. marwanalnimer@yahoo.com
Received: September 10, 2024
Revised: December 9, 2024
Accepted: December 17, 2024
Published online: February 27, 2025
Processing time: 163 Days and 20 Hours
Revised: December 9, 2024
Accepted: December 17, 2024
Published online: February 27, 2025
Processing time: 163 Days and 20 Hours
Core Tip
Core Tip: Sarcopenia and metabolic dysfunction-associated steatotic liver disease (MASLD) share similar risk factors, pathophysiology, and cause (physical inactivity). In both conditions, physical inactivity is a remarkable clinical finding. Determination of irisin in the biological fluids serves as a good marker for physical activity as it elevates during muscle contraction. In sarcopenia, serum irisin declined, while in MASLD it increased. Therefore, a transition of serum irisin from higher to lower levels in MASLD could indicate the occurrence of sarcopenia.