Li C, Nan J, Xu BT. Helicobacter pylori infection as a contributing factor to metabolic dysfunction-associated steatohepatitis: A population-based insight. World J Hepatol 2025; 17(1): 103228 [DOI: 10.4254/wjh.v17.i1.103228]
Corresponding Author of This Article
Chao Li, MD, Assistant Professor, Department of Hepatobiliary Surgery, Zhuji People’s Hospital, No. 9 Jianmin Road, Taozhu Street, Zhuji 311800, Zhejiang Province, China. cszx2002lcrlj@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jan 27, 2025; 17(1): 103228 Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.103228
Helicobacter pylori infection as a contributing factor to metabolic dysfunction-associated steatohepatitis: A population-based insight
Chao Li, Jiang Nan, Bo-Tao Xu
Chao Li, Department of Hepatobiliary Surgery, Zhuji People’s Hospital, Zhuji 311800, Zhejiang Province, China
Jiang Nan, Department of Cosmetic Surgery, Taiyuan Maternity and Child Health Care Hospital, Taiyuan 030000, Shanxi Province, China
Bo-Tao Xu, Department of Cardiothoracic Surgery, Zhuji People’s Hospital, Zhuji 311800, Zhejiang Province, China
Author contributions: Xu BT contributed to validation, writing of the original draft; Nan J contributed to formal analysis, software and validation; Li C contributed to conceptualization, writing, reviewing and editing; All authors participated in drafting the manuscript and all have read, contributed to, and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Li, MD, Assistant Professor, Department of Hepatobiliary Surgery, Zhuji People’s Hospital, No. 9 Jianmin Road, Taozhu Street, Zhuji 311800, Zhejiang Province, China. cszx2002lcrlj@163.com
Received: November 13, 2024 Revised: December 15, 2024 Accepted: December 18, 2024 Published online: January 27, 2025 Processing time: 55 Days and 4.1 Hours
Core Tip
Core Tip: Helicobacter pylori (H. pylori) infection may play an independent role in the development of metabolic dysfunction-associated steatohepatitis, underscoring its influence beyond gastric disease. This association remains significant even after adjusting for key metabolic risk factors, including obesity, type 2 diabetes, and dyslipidemia, suggesting that H. pylori could intensify liver inflammation and insulin resistance through inflammatory pathways, leading to hepatic lipid accumulation. These findings provide a basis for future research into genetic and microbiome-related factors that may modulate the impact of H. pylori on liver pathology, potentially paving the way for targeted interventions in patients vulnerable to metabolic liver disease.
