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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2025; 17(1): 102273
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.102273
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.102273
Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer
Ji Shi, Xu Zhu, Department of Research and Development, Ruibiotech Company Limited, Beijing 100101, China
Jun-Bo Yang, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, Guangdong Province, China
Co-corresponding authors: Xu Zhu and Jun-Bo Yang.
Author contributions: Shi J wrote the manuscript; Zhu X and Yang JB revised it; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Bo Yang, PhD, Associate Professor, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No. 97 Buxin Road, Dapeng New District, Shenzhen 518000, Guangdong Province, China. 1806389316@pku.edu.cn
Received: October 14, 2024
Revised: November 12, 2024
Accepted: November 27, 2024
Published online: January 27, 2025
Processing time: 84 Days and 19.2 Hours
Revised: November 12, 2024
Accepted: November 27, 2024
Published online: January 27, 2025
Processing time: 84 Days and 19.2 Hours
Core Tip
Core Tip: This review delves into the complexities of hepatocellular carcinoma (HCC); a highly aggressive form of liver cancer with a low 5-year survival rate and limited treatment options. It examines various factors contributing to HCC, highlights the need for improved early detection using biomarkers and advanced techniques like next-generation sequencing, and emphasizes the importance of understanding the molecular mechanisms involved, particularly the Wnt/β-catenin signaling pathway, to provide evidence for the development of more effective and personalized therapies.