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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2025; 17(1): 101704
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.101704
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.101704
Effect of alpha-lipoic acid and Silybum marianum supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis
Ana D Cano Contreras, María Del Rocío Francisco, Jose L Vargas Basurto, Kevin D Gonzalez-Gomez, Mercedes Amieva-Balmori, Federico Roesch Dietlen, José M Remes-Troche, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz 91700, Mexico
Author contributions: Cano Contreras AD, Francisco MR, and Remes Troche JM contributed to the study concept and design; Vargas Basurto JL, Gonzalez Gomez KD, and Francisco MR coordinated the study; Vargas Basurto JL, K Gonzalez Gomez KD, Francisco MR, and Cano Contreras AD recruited and treated patients; Cano Contreras AD contributed to data analysis and statistics; Cano Contreras AD, Remes Troche JM, and Roesch Dietlen FB drafted the manuscript; All authors contributed to critical revision of the manuscript.
Institutional review board statement: The study received approval from the research committee of the Universidad Veracruzana.
Clinical trial registration statement: The study was registered as a clinical trial, identification number NCT05913986 (ClinicalTrials.gov).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Cano Contreras AD is a speaker for Medix and Mayoli, Remes Troche JM is a speaker for Carnot and Alfasigma, and the rest of the authors declare that they have no conflicts of interest.
Data sharing statement: The data supporting the results are not available in a public repository. The information is safeguarded by the principal investigator. If further information is required, the corresponding author should be contacted.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ana D Cano Contreras, PhD, Professor, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, C. Agustín de Iturbide, Veracruz 91700, Me
Received: September 24, 2024
Revised: November 8, 2024
Accepted: December 2, 2024
Published online: January 27, 2025
Processing time: 104 Days and 11.2 Hours
Revised: November 8, 2024
Accepted: December 2, 2024
Published online: January 27, 2025
Processing time: 104 Days and 11.2 Hours
Core Tip
Core Tip: Administration of Silybum marianum and alpha-lipoic acid in conjunction with a Mediterranean-style diet demonstrated a decrease in hepatic steatosis as measured by controlled attenuation parameter, improved biochemical parameters, and a reduction in the percentage of visceral fat. In addition to these metabolic benefits, the combination of Silybum marianum and alpha-lipoic acid is considered safe and well-tolerated.