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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2025; 17(1): 100392
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.100392
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.100392
Clinical features of abnormal α-fetoprotein in 15 patients with chronic viral hepatitis B after treatment with antiviral drugs
Man-Lei Jiang, Fei Xu, Jin-Long Li, Jia-Yu Luo, Jiang-Ling Hu, Xian-Qiang Zeng, Ganzhou Institute of Liver Disease, Department of Hepatology, Ganzhou Fifth People's Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Jiang ML designed and conducted the study and wrote the paper; Li JL contributed to the analysis and wrote the paper; Luo JY, Hu JL, Zeng XQ provided clinical advice; and Xu F provided clinical advice and supervised the study.
Institutional review board statement: This study was reviewed and approved by the Ganzhou Fifth People's Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author lffjml@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Man-Lei Jiang, Chief Doctor, Ganzhou Institute of Liver Disease, Department of hepatology, Ganzhou Fifth People's Hospital, No. 666 Dongjiangyuan Avenue, Shuixi Town, Ganzhou 341000, Jiangxi Province, China. lffjml@163.com
Received: August 15, 2024
Revised: November 29, 2024
Accepted: December 17, 2024
Published online: January 27, 2025
Processing time: 143 Days and 23.3 Hours
Revised: November 29, 2024
Accepted: December 17, 2024
Published online: January 27, 2025
Processing time: 143 Days and 23.3 Hours
Core Tip
Core Tip: There is no reasonable explanation for the continuous abnormal increase of α-fetoprotein (AFP) in patients with chronic hepatitis B (CHB) after long-term antiviral therapy and the lack of imaging evidence of liver tumor. We observed 15 patients with CHB treated with antiviral therapy without imaging evidence of liver cancer, and explored the cause of elevated AFP by liver biopsy. Pathological examination suggested that autoimmune hepatitis (AIH) might be complicated, but the diagnosis could not be confirmed by a comprehensive and a simplified diagnostic scoring system for AIH.