Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2025; 17(1): 100377
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.100377
Gut microbiome composition in patients with liver cirrhosis with and without hepatic encephalopathy: A systematic review and meta-analysis
Xiao-Tong Xu, Min-Jie Jiang, Yun-Lai Fu, Fang Xie, Jian-Jun Li, Qing-Hua Meng
Xiao-Tong Xu, Yun-Lai Fu, Fang Xie, Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
Xiao-Tong Xu, Yun-Lai Fu, Jian-Jun Li, Qing-Hua Meng, Interventional Therapy Center for Oncology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
Min-Jie Jiang, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China
Co-first authors: Xiao-Tong Xu and Min-Jie Jiang.
Co-corresponding authors: Jian-Jun Li and Qing-Hua Meng.
Author contributions: Xu XT and Jiang MJ made equal contributions to the data analysis and manuscript writing as co-first authors of this manuscript; Xu XT, Jiang MJ, and Fu YL contributed to the literature database retrieval, data collection, and data extraction; Xu XT, Xie F, Li JJ, and Meng QH conceptualized the topic; Li JJ, Xie F, and Meng QH reviewed the article; Li JJ and Meng QH participated and provided valuable feedback, ensuring the quality of the article and contributing as co-corresponding authors; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Hua Meng, PhD, Professor, Interventional Therapy Center for Oncology, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Received: August 15, 2024
Revised: October 26, 2024
Accepted: November 19, 2024
Published online: January 27, 2025
Processing time: 144 Days and 3 Hours
Core Tip

Core Tip: The gut microbiome is associated with hepatic encephalopathy (HE), but research results on the gut microbiome characteristics of patients with liver cirrhosis with and without HE are inconsistent. We aimed to conduct a meta-analysis of the gut microbiota characteristics of patients with liver cirrhosis with and without HE, to provide a reference for the targeted regulation of the gut microbiota and reduction in HE incidence.