Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2024; 16(9): 1278-1288
Published online Sep 27, 2024. doi: 10.4254/wjh.v16.i9.1278
C23 ameliorates carbon tetrachloride-induced liver fibrosis in mice
Rong-Xing Tang, Xiao-Jun Xie, Yong Xiong, Su Li, Chen Luo, Yi-Gang Wang
Rong-Xing Tang, Yong Xiong, Su Li, Chen Luo, Yi-Gang Wang, Department of Hepatopancreatobiliary Surgery, Panzhihua Municipal Central Hospital, Panzhihua 617000, Sichuan Province, China
Xiao-Jun Xie, Department of Pathology, Panzhihua Maternal and Children Health Hospital, Panzhihua 617000, Sichuan Province, China
Co-first authors: Rong-Xing Tang and Xiao-Jun Xie.
Author contributions: Wang YG and Tang RX conducted conceptualization, Writing; Xie XJ conducted data curation; Xie XJ, Xiong Y and Li S conducted formal analysis; Xiong Y and Li S conducted investigation; Li S and Lou C conducted methodology. All authors have read and agreed to the published version of the manuscript.
Supported by The Panzhihua Science and Technology Planning Project of China, No. 2023ZD-S-57.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the General Hospital of Western Theater Command (protocol No. 2023EC004).
Conflict-of-interest statement: The authors declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Gang Wang, MD, Doctor, Department of Hepatopancreatobiliary Surgery, Panzhihua Municipal Central Hospital, No. 34 Yikang street, East District, Panzhihua 617000, Sichuan Province, China. wyg18096306896@163.com
Received: May 7, 2024
Revised: August 10, 2024
Accepted: August 21, 2024
Published online: September 27, 2024
Processing time: 138 Days and 18.3 Hours
Core Tip

Core Tip: C23, an oligo-peptide derived from cold-inducible RNA-binding protein inhibits the activation of hepatic stellate cells induced with carbon tetrachloride and the expression of collagen I and α-smooth muscle actin. C23 inhibits the expression of liver inflammatory factors and downregulates transforming growth factor-beta/Smad3 pathway activation, thereby alleviating liver fibrosis.