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World J Hepatol. Sep 27, 2024; 16(9): 1258-1268
Published online Sep 27, 2024. doi: 10.4254/wjh.v16.i9.1258
Immune remodulation in pediatric inherited metabolic liver diseases
Yi-Chi Wu, Xue-Lin Xiang, June-Kong Yong, Meng Li, Lin-Man Li, Zi-Cheng Lv, Yi Zhou, Xi-Cheng Sun, Zi-Jie Zhang, Huan Tong, Xiao-Ying He, Qiang Xia, Hao Feng
Yi-Chi Wu, Xue-Lin Xiang, Lin-Man Li, Zi-Cheng Lv, Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
June-Kong Yong, Yi Zhou, Xi-Cheng Sun, Zi-Jie Zhang, Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Meng Li, Qiang Xia, Hao Feng, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Institute of Transplantation, Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai 200127, China
Huan Tong, Xiao-Ying He, Department of Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai 200012, China
Co-first authors: Yi-Chi Wu and Xue-Lin Xiang.
Co-corresponding authors: Hao Feng and Qiang Xia.
Author contributions: Wu YC, Xiang XL, Yong JK, and Li M conceived, designed, and refined the study protocol; Li LM, Zhang ZJ, Tong H, and He XY were involved in the data collection; Lv ZC, Zhou Y, and Sun XC analyzed the data; Wu YC and Feng H drafted the manuscript. All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Wu YC and Xiang XL contributed equally to this work as co-first authors. Xia Q and Feng H contributed equally to this work as co-corresponding authors, which accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the review. Both authors have contributed equally to the conception and design of the research. They have collaboratively developed the hypothesis and outlined the experimental approach. Both authors have been involved in the comprehensive review of the existing literature to establish the research context, identify gaps in knowledge, and support the rationale for the study. They have engaged in intellectual discussions and debates that have shaped the direction of the research, leading to the refinement of ideas and the development of innovative approaches. Both co-corresponding authors have been actively involved in drafting the manuscript, ensuring that the writing reflects their collective thoughts, interpretations, and conclusions drawn from the research.
Supported by Shanghai Science and Technology Development Foundation (Outstanding Academic Leader), No. 23XD1423100; and National Natural Science Foundation, No. 82241221 and No. 92059205.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hao Feng, MD, PhD, Research Scientist, Surgeon, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Institute of Transplantation, Shanghai Engineering Research Center of Transplantation and Immunology, No. 160 Pujian Road, Shanghai 200127, China. surgeonfeng@live.com
Received: January 28, 2024
Revised: May 28, 2024
Accepted: August 19, 2024
Published online: September 27, 2024
Processing time: 239 Days and 10.4 Hours
Core Tip

Core Tip: It remains unclear whether concurrent infections are connected to immunological changes beyond the established metabolic imbalances in inherited metabolic liver diseases. Previous studies often focused on changes in liver parenchyma cells, but recent studies have shown that inherited hepatic metabolic diseases also have a profound impact on the liver’s immune microenvironment.