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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2024; 16(8): 1131-1144
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1131
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1131
Tissue inhibitor of metalloproteinase-3 expression affects clini copathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma
Qiu-Ju Liang, Qin-Qin Long, Feng-Qin Tian, Qun-Ying Su, Xiao-Ying Zhu, Xi-Dai Long, Clinicopathological Diagnosis and Research Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Qiu-Ju Liang, Xi-Dai Long, Department of Tumor Pathology, Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise 533000, Guangxi Zhuang Autonomous Region, China
Co-first authors: Qiu-Ju Liang and Qin-Qin Long.
Author contributions: Liang QJ and Long QQ performed the experiments, formal analysis, and data curation, and they contributed equally to this work and should be considered as co-first authors; Tian FQ, Su QY, and Zhu XY constructed the histopathological sample library and collected the clinicopathological information and following-up data for all patients; Long XD conceptualized and designed the study, received grant support, had full access to the data, and is responsible for the integrity and accuracy of data analysis; all authors contributed to data acquisition and interpretation and reviewed and approved the final version.
Supported by the Science-Technology Planning Project of Guangxi , No. Guike-AD19245174 ; Guangxi Training Program for Medical High-level Academic Leaders , No. 6 of Guiweikejiaofa [2020]-15 ; Bose Talent Highland , No. 2020-3-2 ; Building Projects from the Key Laboratory of Molecular Pathology (Hepatobiliary Diseases) of Guangxi , No. Guiweikejiaofa [2020]-17 ; the Key Laboratory of Tumor Molecular Pathology of Guangxi Colleges and Universities , No. Guijiaokeyan [2022]-10 ; and Clinical Key Specialty Building Project (For Pathology) of Guangxi , No. Guiweiyifa [2022]-21 .
Institutional review board statement: The present study was approved by the Ethics Review Committees of Youjiang Medical University for Nationalities and carried out in accordance with the approved guidelines (No. AYJM20210708).
Informed consent statement: Informed consent from the patients was waived due to the retrospective nature of this study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi-Dai Long, MD, PhD, Professor, Research Scientist, Clinico pathological Diagnosis and Research Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, No. 18 Zhongshan Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. sjtulongxd@ymun.edu.cn
Received: March 6, 2024
Revised: June 27, 2024
Accepted: July 10, 2024
Published online: August 27, 2024
Processing time: 168 Days and 21.4 Hours
Revised: June 27, 2024
Accepted: July 10, 2024
Published online: August 27, 2024
Processing time: 168 Days and 21.4 Hours
Core Tip
Core Tip: This study retrospectively analyzed tissue inhibitor of metalloproteinase-3 (TIMP3) expression and the clini