Zhang L, Cui TX, Li XZ, Liu C, Wang WQ. Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma. World J Hepatol 2024; 16(6): 932-950 [DOI: 10.4254/wjh.v16.i6.932]
Corresponding Author of This Article
Wen-Qin Wang, MMed, Postdoc, Researcher, School of Life Sciences, Shandong University (Qingdao), No. 72 of Binhai Road, Jimo District, Qingdao 26637, Shandong Province, China. wenqinwangsdu@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jun 27, 2024; 16(6): 932-950 Published online Jun 27, 2024. doi: 10.4254/wjh.v16.i6.932
Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma
Li Zhang, Tong-Xing Cui, Xiang-Zhi Li, Chong Liu, Wen-Qin Wang
Li Zhang, Department of Thyroid and Breast Surgery, The Affiliated People Hospital of Second Medical University, Weifang 266010, Shandong Province, China
Tong-Xing Cui, Department of General Surgery, Qingdao Municipal Hospital Group, Qingdao 266237, Shandong Province, China
Xiang-Zhi Li, Wen-Qin Wang, School of Life Sciences, Shandong University (Qingdao), Qingdao 26637, Shandong Province, China
Chong Liu, School of Medicine, Tsinghua University, Beijing 100084, China
Co-first authors: Li Zhang and Tong-Xing Cui.
Author contributions: Zhang L and Cui TX contributed equally to this work and should be considered co-first authors. Wang WQ conceived this study and implemented the experiments; Li XZ and Liu C collected and preprocessed the data; Zhang L and Wang WQ drafted and revised the manuscript.
Supported byFoundation of Qingdao Postdoctoral Innovation Project, No. QDBSH20230101019; and Funded State Key Laboratory of Marine Food Processing & Safety Control, Qingdao, No. SKL2023M05.
Institutional review board statement: The study was approved by the Ethical Review Committee of Qingdao Municipal Hospital College, No. QDSSLYY2023CB22.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset were available from the corresponding author at wenqinwangsdu@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Qin Wang, MMed, Postdoc, Researcher, School of Life Sciences, Shandong University (Qingdao), No. 72 of Binhai Road, Jimo District, Qingdao 26637, Shandong Province, China. wenqinwangsdu@163.com
Received: January 23, 2024 Revised: April 8, 2024 Accepted: April 28, 2024 Published online: June 27, 2024 Processing time: 148 Days and 17.6 Hours
Core Tip
Core Tip: LINC01767 was down-regulated based on The Cancer Genome Atlas and GSE dataset. It was positively with the cancer stemness in hepatocellular carcinoma (HCC) based on the single cell sequence data. LINC01767 demonstrate a good diagnostic and diagnostic performance. The 9-gene model demonstrated better performance than the 5-gene model in predicting the overall survival of HCC patients using least absolute shrinkage and selection operator regression, with an area under the curve greater than 0.75. LINC01767 was down regulated obviously in tumor than para-tumor tissues in our cohort. LINC01767 was down regulated in cancer cell line comparing with LO2; the over expression of LINC01767 inhibit the cell proliferation and impede the clone formation of Huh7 in vitro.
