Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2024; 16(6): 883-890
Published online Jun 27, 2024. doi: 10.4254/wjh.v16.i6.883
Cold ischemia time in liver transplantation: An overview
Manuela Cesaretti, Alessandro Izzo, Roberta Anna Pellegrino, Alessandro Galli, Orestes Mavrothalassitis
Manuela Cesaretti, Alessandro Izzo, Roberta Anna Pellegrino, Department of HPB and Liver Transplantation, Brotzu Hospital, Cagliari 09122, Italy
Manuela Cesaretti, Department of Nanophysic, Istituto Italiano di Tecnologia, Genova 16163, Italy
Alessandro Galli, Department of Critical Care Medicine and Anesthesia, ASST Papa Giovanni XXIII, Bergamo 24100, Italy
Alessandro Galli, Orestes Mavrothalassitis, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143, United States
Co-corresponding authors: Manuela Cesaretti and Orestes Mavrothalassitis.
Author contributions: Cesaretti M, Izzo A, Galli A, and Pellegrino RA drafted the article, revised it critically for important intellectual content; Cesaretti M and Mavrothalassitis O contributed to conception and design, acquisition, analysis and interpretation of data; Cesaretti M and Mavrothalassitis O gave the final approval of the version to be published, they are co-corresponding authors of this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Manuela Cesaretti, MD, PhD, Assistant Professor, Surgeon, Department of HPB and Liver Transplantation, Brotzu Hospital, 100 Boulevard du Général Leclerc, Cagliari 09122, Italy. manuela.csr02@gmail.com
Received: March 4, 2024
Revised: April 26, 2024
Accepted: May 20, 2024
Published online: June 27, 2024
Processing time: 107 Days and 13.7 Hours
Core Tip

Core Tip: Many variables affect liver transplantation outcomes. Among these variables, cold ischemia time (CIT), defined as the time from the cold flushing of the donor organ until the graft is removed from ice to be implanted into the recipient, is the one of the most important and is incorporated into many predictive scoring systems. CIT is a multifactorial variable that depends on donor hepatectomy time, transit time and recipient surgery time and can only be calculated retrospectively.