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World J Hepatol. May 27, 2024; 16(5): 776-783
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.776
Microbiota treatment of functional constipation: Current status and future prospects
Yan Li, Xiao-Han Zhang, Zi-Kai Wang
Yan Li, Xiao-Han Zhang, Zi-Kai Wang, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Xiao-Han Zhang, Medical School, Nankai University, Tianjin 300071, China
Zi-Kai Wang, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Li Y and Zhang XH wrote this manuscript and contributed equally; Wang ZK conceived and edited the manuscript.
Supported by the Project of the National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, No. NCRCG-PLAGH-2023005.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zi-Kai Wang, Doctor, MD, Associate Chief Physician, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wangzikai301@126.com
Received: December 27, 2023
Revised: February 5, 2024
Accepted: April 3, 2024
Published online: May 27, 2024
Processing time: 147 Days and 1.9 Hours
Core Tip

Core tip: Intestinal microbiota imbalance participates in functional constipation (FC) development. Gut microbiota modulation has potential clinical applications in the treatment of FC. The efficacy of specialized microbiota modulators and fecal microbiota transplantation should be explored.