Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2024; 16(5): 703-715
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.703
Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease
Li Xu, Yu-Hong Fan, Xiao-Jing Zhang, Lan Bai
Li Xu, Yu-Hong Fan, Lan Bai, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou 341000, China
Xiao-Jing Zhang, School of Basic Medical Sciences, Wuhan University, Wuhan 430060, China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou 341000, China
Co-first authors: Li Xu and Yu-Hong Fan.
Author contributions: Xu L and Fan YH contributed equally to this work; Xu L and Fan YH reviewed and analyzed the literature; All authors contributed to the writing and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lan Bai, PhD, Professor, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases; Gannan Innovation and Translational Medicine Research Institute; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education; Gannan Medical University, Huangjin Campus, University Town, Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. bailan@gmu.edu.cn
Received: December 28, 2023
Revised: February 9, 2024
Accepted: April 7, 2024
Published online: May 27, 2024
Processing time: 146 Days and 4.4 Hours
Core Tip

Core Tip: Non-alcoholic fatty liver disease (NAFLD) is a global health concern accounting for a significant proportion of liver-related deaths. However, there are no Food and Drug Administration-approved drugs for NAFLD treatment. Epigenetic mechanisms play multiple roles in the pathogenesis of diseases and hold promise as potential therapeutic targets. Here, we review the impact of histone methylation on the alterations in metabolic homeostasis, inflammatory injury, fibrosis, and carcinogenesis during the progression of NAFLD, providing a theoretical foundation for target discovery and clinical treatment.