Fecal microbiota transplantation in the treatment of hepatic encephalopathy: A perspective

doi:10.4254/wjh.v16.i5.678

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May 27, 2024 (publication date) through Jun 28, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. May 27, 2024; 16(5): 678-683
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.678

Fecal microbiota transplantation in the treatment of hepatic encephalopathy: A perspective

Arghya Samanta, Moinak Sen Sarma

Arghya Samanta, Moinak Sen Sarma, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India

Author contributions: Samanta A did the literature review and wrote the original manuscript; Sen Sarma M did critical analysis, reviewed and revised the manuscript; All authors approved the final version of the manuscript.

Conflict-of-interest statement: All authors declare no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Moinak Sen Sarma, MBBS, MD, Adjunct Associate Professor, Doctor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. moinaksen@yahoo.com

Received: January 23, 2024
Revised: March 6, 2024
Accepted: April 16, 2024
Published online: May 27, 2024
Processing time: 119 Days and 23.8 Hours

Core Tip

Core Tip: Hepatic encephalopathy (HE) remains one of the most dreaded and difficult-to-treat complications in patients with cirrhosis. Alteration in the number and diversity of microorganisms in the human intestinal tract appears to have profound effect in the pathophysiology of HE in cirrhotic patients. Targeting gut dysbiosis by fecal microbiota transplantation is a promising therapeutic modality.