Liver disease in patients with transfusion-dependent β-thalassemia: The emerging role of metabolism dysfunction-associated steatotic liver disease

doi:10.4254/wjh.v16.i5.671

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May 27, 2024 (publication date) through Nov 26, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. May 27, 2024; 16(5): 671-677
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.671

Liver disease in patients with transfusion-dependent β-thalassemia: The emerging role of metabolism dysfunction-associated steatotic liver disease

Nikolaos Fragkou, Efthimia Vlachaki, Ioannis Goulis, Emmanouil Sinakos

Nikolaos Fragkou, Ioannis Goulis, Emmanouil Sinakos, 4^th Department of Internal Medicine, Hippokratio Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece

Efthimia Vlachaki, 2^nd Department of Internal Medicine, Hippokratio Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece

Author contributions: Fragkou N drafted the article; Vlachaki E, Goulis I and Sinakos E designed the study, made critical revisions related to important intellectual content of the manuscript and approved the final version of the study.

Conflict-of-interest statement: All authors have no conflict of interest to declare.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Emmanouil Sinakos, MD, PhD, Assistant Professor, 4^th Department of Internal Medicine, Hippokratio Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos Str. 49, Thessaloniki 54642, Greece. em_sinakos@yahoo.com

Received: December 27, 2023
Revised: March 2, 2024
Accepted: April 17, 2024
Published online: May 27, 2024
Processing time: 146 Days and 20.2 Hours

Core Tip

Core Tip: Transfusion-dependent β-Thalassemia (TDBT) is one of the most frequent congenital diseases. Advances in the care of patients with TDBT over the past two decades have managed to significantly increase their life expectancy, making them more vulnerable to the onset of diseases related to the metabolic syndrome. Recent data from a relatively small study have highlighted the significance of the presence of hepatic steatosis in these patients. We herein discuss the available data concerning the presence of hepatic steatosis in this population, and the potential implications that these findings could have in the management of patients with TDBT, should these results be confirmed in larger cohorts.