Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2024; 16(3): 405-417
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.405
Prediction model for hepatitis B e antigen seroconversion in chronic hepatitis B with peginterferon-alfa treated based on a response-guided therapy strategy
Pei-Xin Zhang, Xiao-Wei Zheng, Ya-Fei Zhang, Jun Ye, Wei Li, Qian-Qian Tang, Jie Zhu, Gui-Zhou Zou, Zhen-Hua Zhang
Pei-Xin Zhang, Ya-Fei Zhang, Jun Ye, Qian-Qian Tang, Jie Zhu, Gui-Zhou Zou, Zhen-Hua Zhang, Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Xiao-Wei Zheng, Department of Infectious Diseases, Anhui Provincial Hospital, Hefei 230000, Anhui Province, China
Wei Li, Department of Hepatology, The Second People’s Hospital of Fuyang City, Fuyang 236000, Anhui Province, China
Author contributions: Zhang PX and Zheng XW contributed to the data analysis and drafting of the manuscript; Zhang PX, Zheng XW, Zhang YF, Ye J, Li W, Tang QQ, and Zou GZ contributed to the data acquisition; Zhang YF, Zhu J, Zou GZ, and Zhang ZH contributed in the process assessment; Zhang ZH contributed in the study conception and design; and all authors have read and approved the final version of the manuscript.
Supported by the Anhui Provincial Natural Science Foundation, No. 2108085MH298; the Scientific Research Project of the Second Affiliated Hospital of Anhui Medical University, No. 2019GMFY02 and 2021lcxk027; and the Scientific Research Project of Colleges and Universities in Anhui Province, No. KJ2021A0323.
Institutional review board statement: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee (Anhui Medical University No. 2012624) and with the 1975 Helsinki Declaration.
Informed consent statement: Written informed consent was obtained from all patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at zzh1974cn@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Hua Zhang, MD, Professor, Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. zzh1974cn@163.com
Received: November 7, 2023
Peer-review started: November 7, 2023
First decision: December 6, 2023
Revised: December 27, 2023
Accepted: February 1, 2024
Article in press: February 1, 2024
Published online: March 27, 2024
Core Tip

Core Tip: This study identified the optimal independent predictors of treatment response in previously treated patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B who received peginterferon alpha therapy. Using single-factor and multi-factor logistic regression analyses, scoring prediction models and response-guided therapy strategies were established. These tools offer guidance for physicians to adjust treatment plans for patients who have not achieved HBeAg seroconversion after long-term nucleos(t)ide analog therapy, carrying significant practical implications for alleviating social and medical burdens.