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World J Hepatol. Mar 27, 2024; 16(3): 344-352
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.344
Protein succinylation, hepatic metabolism, and liver diseases
Shuang Liu, Rui Li, Ya-Wen Sun, Hai Lin, Hai-Fang Li
Shuang Liu, Hai Lin, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai’an 271018, Shandong Province, China
Rui Li, Ya-Wen Sun, Hai-Fang Li, College of Life Sciences, Shandong Agricultural University, Tai’an 271018, Shandong Province, China
Co-first authors: Shuang Liu and Rui Li.
Author contributions: Liu S and Li R wrote the original draft, created the figures, and revised the manuscript; Sun YW wrote the original draft and created the figures; Lin H supervised and verified the paper; Li HF supervised, conceived, verified, reviewed, and edited the manuscript; All authors were involved in the critical review of the results and have contributed to reading and approving the final manuscript. Liu S and Li R contributed equally to this work as co-first authors. The reasons for designating Liu S and Li R as co-first authors are twofold. First, the review was prepared as a collaborative effort with Liu S and Li R contributing equally to literature searching, draft writing, figure drawing, and manuscript revising. The designation of co-first authors authorship reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the review and ensure effective communication and management of post-submission matters. Second, Liu S and Li R are skilled in different fields, which promotes the most comprehensive and in-depth discussion of the review topic, ultimately enriching reader understanding by offering various expert perspectives.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Fang Li, Doctor, Associate Professor, College of Life Sciences, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, Shandong Province, China. haifangli@sdau.edu.cn
Received: December 11, 2023
Peer-review started: December 11, 2023
First decision: December 29, 2023
Revised: January 8, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: March 27, 2024
Processing time: 107 Days and 5.3 Hours
Core Tip

Core Tip: Succinylation is the process of transferring succinyl groups through enzymatic and non-enzymatic means using succinyl CoA as a direct substrate. The succinylation degree could be promoted by succinyltransferases (e.g., lysine acetyltransferase 2A, histone acetyltransferase 1, α-ketoglutarate dehydrogenase complex, and carnitine palmitoyltransferase 1A). Desuccinylases including CobB, sirtuin 5, and sirtuin 7 negatively regulate protein succinylation. Several proteins and enzymes in glucose, amino acid, and lipid metabolisms are succinylated in the liver. Succinylation is associated with the progression of several liver diseases. Proteins with varied levels of succinylation may be potential targets for the treatment of fatty liver, hepatitis, and hepatocellular carcinoma.