Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 27, 2024; 16(11): 1331-1338
Published online Nov 27, 2024. doi: 10.4254/wjh.v16.i11.1331
Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis: Systematic review and meta-analysis
Nirav Agrawal, Scarlet Louis-Jean, Zoya Ladiwala, Harsha Adnani, Ayesha Kamal, Mitchell Karpman, Albert Steven Fleisher, Sanmeet Singh
Nirav Agrawal, Scarlet Louis-Jean, Zoya Ladiwala, Harsha Adnani, Ayesha Kamal, Department of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, United States
Mitchell Karpman, Department of Biostatistics, Anne Arundel Medical Center, Annapolis, MD 21401, United States
Albert Steven Fleisher, Sanmeet Singh, Department of Gastroenterology, Anne Arundel Medical Center, Annapolis, MD 21401, United States
Author contributions: Agrawal N, Ladiwala Z, Adnani H, Kamal A, created the project concept, Ladiwala Z, Adnani H, Kamal A, helped with data extraction and data synthesis. Agrawal N, Louis-Jean S and Karpman M, helped with the data analysis and data interpretation. Louis-Jean S and Agrawal N helped writing the manuscript. Fleisher SA, and Singh S were mentors helping in each step of the process and guidance.
Conflict-of-interest statement: There are no conflict of interest to declare for this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nirav Agrawal, MBBS, MD, Researcher, Department of Internal Medicine, Anne Arundel Medical Center, 2001 Medical Parkway, Annapolis, MD 21401, United States. nirav1191@gmail.com
Received: July 28, 2024
Revised: September 1, 2024
Accepted: October 8, 2024
Published online: November 27, 2024
Processing time: 100 Days and 18 Hours
Core Tip

Core Tip: The findings of this systematic review and meta-analysis supports that neutrophil gelatinase-associated lipocalin (NGAL) can reliably predict acute tubular necrosis (ATN) among patients with decompensated cirrhosis. 2. The pooled diagnostic odds ratio of 22.15 (95%CI: 17.58-27.89) from 14 studies indicates a strong correlation between high urinary NGAL levels and the presence of ATN in cirrhosis patients with acute kidney injury.