Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality
Xiao-Quan Huang, Ling Wu, Chun-Yan Xue, Chen-Yi Rao, Qing-Qing Fang, Ying Chen, Cao Xie, Sheng-Xiang Rao, Shi-Yao Chen, Feng Li
Xiao-Quan Huang, Ling Wu, Chun-Yan Xue, Chen-Yi Rao, Shi-Yao Chen, Feng Li, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Qing-Qing Fang, Ying Chen, Shi-Yao Chen, Feng Li, Department of Gastroenterology, Minhang Hospital, Fudan University, Shanghai 201100, China
Cao Xie, Department of Pharmacy, Fudan University, Shanghai 200032, China
Sheng-Xiang Rao, Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Co-first authors: Xiao-Quan Huang and Ling Wu.
Author contributions: Li F and Huang XQ designed the research study; Huang XQ, Wu L, Xue CY, Rao CY, Fang QQ and Chen Y performed the research; Huang XQ, Wu L, Xue CY and Rao CY collected and analyzed data; Xie C and Rao SX conducted animal imaging and analysis; Wu L and Huang XQ wrote the manuscript; Li F, Huang XQ, Wu L, Chen SY revised the manuscript; All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81670513; and Young Scientists Fund of the National Natural Science Foundation of China, No. 81900511.
Institutional review board statement: This study does not involve human subject research.
Institutional animal care and use committee statement: This study was performed in line with the Declaration of Helsinki and the ethical approval was obtained from the Institutional Ethical Committee of Animal Experimentation, Zhongshan Hospital affiliated to Fudan University.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Data will be made available upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Feng Li, MD, Chief Physician, Research Scientist, Senior Scientist, Staff Physician, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China.
li.feng2@zs-hospital.sh.cn
Received: March 26, 2024
Revised: August 27, 2024
Accepted: October 20, 2024
Published online: November 27, 2024
Processing time: 224 Days and 14.9 Hours
