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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2023; 15(7): 925-938
Published online Jul 27, 2023. doi: 10.4254/wjh.v15.i7.925
Published online Jul 27, 2023. doi: 10.4254/wjh.v15.i7.925
Associations between irritable bowel syndrome and non-alcoholic fatty liver disease: A systematic review
Jareth Jun Jie Ng, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Wai Mun Loo, AliveoMedical, Mount Alvernia and Mount Elizabeth Hospitals, Singapore 574623, Singapore
Kewin Tien Ho Siah, Division of Gastroenterology and Hepatology, National University Hospital, Singapore 119228, Singapore
Kewin Tien Ho Siah, Department of Medicine, National University Hospital, Singapore 119228, Singapore
Author contributions: Siah KTH contributed to the design and implementation of the research and supervision; Ng JJJ and Loo WM performed the analysis of the results and writing of the manuscript.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised accordingly to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kewin Tien Ho Siah, MD, Division of Gastroenterology and Hepatology, National University Hospital, NUHS Tower Block, Level 10, 1E Kent Ridge Road, Singapore 119228, Singapore. kewin_siah@nuhs.edu.sg
Received: March 26, 2023
Peer-review started: March 26, 2023
First decision: May 15, 2023
Revised: June 12, 2023
Accepted: July 3, 2023
Article in press: July 3, 2023
Published online: July 27, 2023
Peer-review started: March 26, 2023
First decision: May 15, 2023
Revised: June 12, 2023
Accepted: July 3, 2023
Article in press: July 3, 2023
Published online: July 27, 2023
Core Tip
Core Tip: The relationship between irritable bowel syndrome (IBS) and non-alcoholic fatty liver disease (NAFLD) is increasingly recognised but their shared mechanisms remain poorly elucidated. We evaluate the association between IBS and NAFLD and discuss the risk factors and possible common mechanistic pathways including the brain-gut-liver axis, gut dysbiosis and translocation, altered hypothalamic-pituitary-adrenal axis and sleep quality.