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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2023; 15(6): 841-849
Published online Jun 27, 2023. doi: 10.4254/wjh.v15.i6.841
Published online Jun 27, 2023. doi: 10.4254/wjh.v15.i6.841
Liver injury from direct oral anticoagulants
Deven Juneja, Institute of Critical Care Medicine, Max Super Specialty Hospital, New Delhi 110017, India
Prashant Nasa, Critical Care Medicine, NMC Specialty Hospital, Dubai 7832, United Arab Emirates
Prashant Nasa, Internal Medicine, College of Medicine and Health Sciences, Al Ain 15551, United Arab Emirates
Ravi Jain, Critical Care Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur 302001, Rajasthan, India
Author contributions: Nasa P conceptualized and designed the article; Juneja D, Nasa P, and Jain R performed acquisition of data, analysis and interpretation of data, and drafted the article; Juneja D and Jain R revised the article; and all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prashant Nasa, MD, Chief Doctor, Critical Care Medicine, NMC Specialty Hospital, Amman Street, Al Nahda 2, Dubai 7832, United Arab Emirates.
Received: January 5, 2023
Peer-review started: January 5, 2023
First decision: January 19, 2023
Revised: January 23, 2023
Accepted: May 15, 2023
Article in press: May 15, 2023
Published online: June 27, 2023
Processing time: 170 Days and 22.6 Hours
Peer-review started: January 5, 2023
First decision: January 19, 2023
Revised: January 23, 2023
Accepted: May 15, 2023
Article in press: May 15, 2023
Published online: June 27, 2023
Processing time: 170 Days and 22.6 Hours
Core Tip
Core Tip: Drug-induced liver injury (DILI) can be ascribed to practically any prescribed drug. The side effect profile of relatively newer direct-acting oral anticoagulants (DOACs) is yet to be completely determined. Even though the data from earlier clinical trials suggested no significant liver toxicity, several case reports and series describing DOAC-induced DILI have been recently published. Most of these cases have been reported in elderly patients, not on concomitant hepatotoxic drugs. However, these patients may have good clinical outcomes, with complete recovery of liver function, if an early diagnosis is made and the offending agent is stopped.