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World J Hepatol. Feb 27, 2023; 15(2): 208-215
Published online Feb 27, 2023. doi: 10.4254/wjh.v15.i2.208
Clostridioides difficile infection in patients with nonalcoholic fatty liver disease-current status
Yana V Kiseleva, Roman V Maslennikov, Aida N Gadzhiakhmedova, Tatyana S Zharikova, Dmitry V Kalinin, Yury O Zharikov
Yana V Kiseleva, International School “Medicine of the Future”, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
Roman V Maslennikov, Department of Internal Medicine, Gastroenterology and Hepatology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia
Roman V Maslennikov, Department of Internal Medicine, Сonsultative and Diagnostic Center No. 2, Moscow City Health Department, Moscow 107564, Russia
Aida N Gadzhiakhmedova, Tatyana S Zharikova, Yury O Zharikov, Department of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 125009, Russia
Dmitry V Kalinin, Department of Pathology, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 115093, Russia
Author contributions: Kiseleva YV is responsible for conceptualization, supervision, manuscript first draft preparation, approved final draft; Maslennikov RV is responsible for supervision, data acquisition, approved final draft; Gadzhiakhmedova AN is responsible for data acquisition, visualization, manuscript writing and editing, approved final draft; Zharikova TS is responsible for data aquisiton, formal analysis, manuscript writing and editing, approved final draft; Kalinin DV is responsible for visualization, formal analysis, manuscript writing, review and editing, approved final draft; Zharikov YO is responsible for supervision, conceptualization, manuscript first draft preparation, review and editing, approved final draft.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yury O Zharikov, MD, PhD, Associate Professor, Surgeon, Department of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Mokhovaya Street, 11s10, Moscow 125009, Russia. dr_zharikov@mail.ru
Received: October 23, 2022
Peer-review started: October 23, 2022
First decision: December 12, 2022
Revised: December 26, 2022
Accepted: January 31, 2023
Article in press: January 31, 2023
Published online: February 27, 2023
Processing time: 123 Days and 22.9 Hours
Core Tip

Core Tip: The association of nonalcoholic fatty liver disease (NAFLD) with Clostridioides difficile (C. difficile) infection (CDI) has been shown in only 4 studies to date, three of which included less than 1000 patients, although the frequency of NAFLD in these studies was observed in almost 20% of the total patient cohort. These data revealed that NAFLD is a risk factor for CDI development and, moreover, is a risk factor for intestinal complications of CDI. More retrospective studies and systematic reviews are needed to examine this group of patients as a risk factor for CDI, make recommendations to prevent CDI, and effectively screen and diagnose C. difficile colonization within NAFLD patients.