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World J Hepatol. Jan 27, 2023; 15(1): 52-67
Published online Jan 27, 2023. doi: 10.4254/wjh.v15.i1.52
Liver immunity, autoimmunity, and inborn errors of immunity
Yavuz Emre Parlar, Sefika Nur Ayar, Deniz Cagdas, Yasemin H Balaban
Yavuz Emre Parlar, Yasemin H Balaban, Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
Sefika Nur Ayar, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
Deniz Cagdas, Department of Pediatric Immunology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara 06100, Turkey
Author contributions: Parlar YE and Balaban YH contributed equally in collecting the data and writing the paper; Ayar SN and Cagdas D edited the manuscript and contributed opinions on liver immunity; all authors have read and approved the final manuscript.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yavuz Emre Parlar, MD, Research Fellow, Department of Gastroenterology, Hacettepe University Faculty of Medicine, Hacettepe University Sihhiye Campus, 06100 Sihhiye/Ankara, Ankara 06100, Turkey. yavuzemreparlar@gmail.com
Received: September 17, 2022
Peer-review started: September 17, 2022
First decision: October 22, 2022
Revised: October 23, 2022
Accepted: December 23, 2022
Article in press: December 23, 2022
Published online: January 27, 2023
Core Tip

Core Tip: The various repertoires of immune cell populations in the liver play a central role in maintaining homeostasis between inflammation and tolerance. Inflammatory and immunoregulatory interactions within the liver are essential for maintaining systemic homeostasis. In this review, we summarize the molecular mechanisms involved in these seemingly contradictory immune processes and how liver immunity functions during normal liver homeostasis and liver pathologies, such as viral hepatitis, autoimmune hepatitis, and hepatocellular cancer.