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World J Hepatol. Jan 27, 2023; 15(1): 41-51
Published online Jan 27, 2023. doi: 10.4254/wjh.v15.i1.41
Acute-on-chronic liver failure in patients with severe acute respiratory syndrome coronavirus 2 infection
Peter Liptak, Lenka Nosakova, Robert Rosolanka, Lubomir Skladany, Peter Banovcin
Peter Liptak, Lenka Nosakova, Peter Banovcin, Clinic of Internal Medicine-Gastroenterology, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University, Martin 03601, Slovakia
Robert Rosolanka, Clinic of Infectology and Travel Medicine, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University, Martin 03601, Slovakia
Lubomir Skladany, Department of Internal Medicine II, Division Hepatology, Gastroenterology and Liver Transplantation, FD Roosevelt University Hospital of Slovak Medical University, Banska Bystrica 97517, Slovakia
Author contributions: Liptak P wrote the manuscript, prepared the figure and completed the manuscript; Nosakova L and Rosolanka R wrote the manuscript and prepared the tables; Skladany L and Banovcin P supervised and coordinated manuscript preparation.
Supported by Research and Development of a Telemedicine System to Support the Monitoring of the Possible Spread of COVID-19 in Order to Develop Analytical Tools Used to Reduce the Risk of Infection, No. ITMS: 313011ASX4.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior authors or other coauthors who contributed their efforts to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lenka Nosakova, MD, PhD, Doctor, Clinic of Internal Medicine-Gastroenterology, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University, Kollarova 2, Martin 03601, Slovakia. lenka.bubernakova@gmail.com
Received: September 13, 2022
Peer-review started: September 13, 2022
First decision: October 20, 2022
Revised: November 3, 2022
Accepted: November 28, 2022
Article in press: November 28, 2022
Published online: January 27, 2023
Processing time: 124 Days and 14.7 Hours
Core Tip

Core Tip: The main aim of this brief review is to summarize current knowledge on the acute-on-chronic liver failure (ACLF) in patients with coronavirus disease 2019 (COVID-19). We also describe several mechanisms by which severe acute respiratory syndrome coronavirus 2 infection induces liver injury. Although several systematic reviews have already been published regarding liver impairment in COVID-19, there are few studies focusing on ACLF. We believe that this brief review has an informative value for clinicians and could contribute to better understanding of the disease and therefore improved management of this serious condition.