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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise
Amit Kumar Singh, Department of Botany, Government Naveen Girls College, Balod (Hemc
Amit Kumar Singh, Shiv Vardan Singh, Ramesh Kumar, Abhay K Pandey, Department of Biochemistry, University of Allahabad, Prayagraj 211002, Uttar Pradesh, India
Ramesh Kumar, Shashank Kumar, Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151401, Punjab, India
Sabyasachi Senapati, Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda 151401, Punjab, India
Author contributions: Pandey AK conceptualized the idea; Singh AK, Singh SV, Kumar R, Kumar S and Senapati S performed the literature search and wrote the first draft of the manuscript; Kumar R and Singh SV validated the references; Kumar S and Pandey AK critically reviewed and revised the manuscript; Pandey AK supervised the project; all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abhay K Pandey, PhD, Professor, Department of Biochemistry, University of Allahabad, University Road, Prayagraj 211002, Uttar Pradesh, India.
Received: April 30, 2022
Peer-review started: April 30, 2022
First decision: May 29, 2022
Revised: July 2, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 27, 2023
Processing time: 260 Days and 8.7 Hours
Peer-review started: April 30, 2022
First decision: May 29, 2022
Revised: July 2, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 27, 2023
Processing time: 260 Days and 8.7 Hours
Core Tip
Core Tip: Liver cancer is a serious public health concern and its therapy is stage-dependent. Approximately 75% of all liver cancers are hepatocellular carcinoma, which is regarded as primary liver cancer. First and second-line therapies are used to manage the disease but they have their own limitations in terms of toxicity and other severe side effects. Natural products are the prime choice for the future treatment of liver cancer. With advancement in the knowledge about the molecular mechanism of the disease, newer strategies having fewer side effects and greater effectiveness are needed.