Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2022; 14(9): 1804-1816
Published online Sep 27, 2022. doi: 10.4254/wjh.v14.i9.1804
Hereditary hemochromatosis: Temporal trends, sociodemographic characteristics, and independent risk factor of hepatocellular cancer – nationwide population-based study
Maryam Bilal Haider, Ali Al Sbihi, Ahmed Jamal Chaudhary, Syed M Haider, Ahmed Iqbal Edhi
Maryam Bilal Haider, Ali Al Sbihi, Ahmed Jamal Chaudhary, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Sinai Grace Hospital, Detroit, MI 48235, United States
Syed M Haider, System Science, Binghamton University, Binghamton, NY 13902, United States
Ahmed Iqbal Edhi, Department of Gastroenterology, William Beaumont Hospital, Royal Oak, MI 48073, United States
Author contributions: Haider M was responsible for study design and interpretations of results; Haider M and Al Sbihi A were responsible for literature review and manuscript preparation; Haider S was responsible for data collection; Chaudhary A and Edhi A were responsible for the overall supervision and final approval.
Institutional review board statement: Data from this study used de-identified data from the National Inpatient Sample Database (NIS) 2011-2019. A publicly available all-payer inpatient care database in the United States. Institutional Review Board Approval Form or Document is not required.
Informed consent statement: Data from this study used de-identified data from the National Inpatient Sample Database. A publicly available all-payer inpatient care database in the United States. Informed patient consent is not required.
Conflict-of-interest statement: All authors declare no conflict of interests for this article.
Data sharing statement: Data that support the findings of this study are publicly available at https://www.hcup-us.ahrq.gov/db/nation/nis/nisdbdocumentation.jsp.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maryam Bilal Haider, MD, Doctor, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Sinai Grace Hospital, 6071 Outer Dr W, Detroit, MI 48235, United States. maryambilalhaider@yahoo.com
Received: May 5, 2022
Peer-review started: May 5, 2022
First decision: June 8, 2022
Revised: June 20, 2022
Accepted: August 25, 2022
Article in press: August 25, 2022
Published online: September 27, 2022
Core Tip

Core Tip: Our study is a National Inpatient Sample -based study in which we aim to analyze hereditary hemochromatosis (HH) patients’ characteristics, temporal trends, and sociodemographic characteristics over the last decade, in addition to studying this disease as an independent risk factor for developing hepatocellular cancer (HCC) without the stage of liver cirrhosis. Our large and diverse sample of about 18000 HH hospitalizations showed an increasing trend of inpatient admissions and costs with a similar length of hospital stay over the last decade. It also showed HH as an independent risk factor for HCC with an aOR close to 29 on multivariate analysis. We believe this will open the door for further retrospective and prospective studies to address disease trends and the understudied and independent relationship between HH and HCC in a large patient cohort.