Retrospective Cohort Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2022; 14(9): 1757-1766
Published online Sep 27, 2022. doi: 10.4254/wjh.v14.i9.1757
Positive autoantibodies in living liver donors
Joyce Loh, Koji Hashimoto, Choon Hyuck David Kwon, Masato Fujiki, Jamak Modaresi Esfeh
Joyce Loh, Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Koji Hashimoto, Choon Hyuck David Kwon, Masato Fujiki, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Jamak Modaresi Esfeh, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Author contributions: Loh J designed, performed the research and analysis of the data and wrote the paper; Hashimoto K, Kwon CD, and Masato F helped with critical revisions of the study; Modaresi Esfeh J supervised, helped design the study, made critical revisions to the manuscript and gave final approval.
Institutional review board statement: This study was reviewed and approved by the Cleveland Clinic Foundation Institutional Review Board.
Informed consent statement: This study qualified by a Waiver of Informed Consent as determined by our hospital’s IRB as it was a retrospective study that involved no more than minimal risk to the subjects, could be reasonably carried out without the waiver, and was not a threat to the rights or welfare of the subjects.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jamak Modaresi Esfeh, MD, Staff Physician, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, United States. modarej@ccf.org
Received: May 5, 2022
Peer-review started: May 5, 2022
First decision: June 8, 2022
Revised: June 17, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: September 27, 2022
Processing time: 140 Days and 22.3 Hours
Core Tip

Core Tip: This was a retrospective study designed to analyze the significance of positive autoantibodies in donors on post-transplant outcomes in recipients in living donor liver transplantations. Post-transplantation rates of complications including mortality (P value = 1), infections (P value = 0.66), anastomotic strictures (P value = 0.07), and rejection (P value = 0.30) were found not to be statistically significant between the autoantibody positive and negative groups. These results suggest that isolated pre-transplant autoantibody positivity is not correlated to worse post-transplant outcomes in living liver donor transplants and should not preclude donors from donating.