Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2022; 14(8): 1687-1691
Published online Aug 27, 2022. doi: 10.4254/wjh.v14.i8.1687
Published online Aug 27, 2022. doi: 10.4254/wjh.v14.i8.1687
Hemorrhagic colitis induced by trientine in a 51-year-old patient with Wilson’s disease waiting for liver transplantation: A case report
Andreas Schult, Transplant Institute, Sahlgrenska University Hospital, Gothenburg 41345, Sweden
Andreas Schult, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41345, Sweden
Matts Andersson, Department of Medicine, Örnsköldsvik Hospital, Örnsköldsvik 89145, Sweden
Jorge Asin-Cayuela, Department of Clinical Genetics, Sahlgrenska University Hospital, Gothenburg 41345, Sweden
Karl Sigvard Olsson, Section of Hematology and Coagulation, Department of Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41345, Sweden
Author contributions: Schult A wrote the part of the manuscript concerning transplantation, pretransplant work-up and revised the manuscript; Andersson M contributed to pretransplant clinical information; Asin-Cayuela J wrote the part concerning genetic analyses and critically revised the manuscript; Olsson KS drafted the main manuscript and critically revised the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: All authors have nothing to declare.
CARE Checklist (2016) statement: The current case report follows the CARE checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andreas Schult, MD, Consultant Physician-Scientist, Transplant Institute, Sahlgrenska University Hospital, Bruna Stråket 5, Gothenburg 41345, Sweden. andreas.schult@vgregion.se
Received: March 3, 2022
Peer-review started: March 3, 2022
First decision: June 8, 2022
Revised: July 1, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 27, 2022
Peer-review started: March 3, 2022
First decision: June 8, 2022
Revised: July 1, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 27, 2022
Core Tip
Core Tip: Even if Wilson’s disease is a rare disorder, it is important to consider as a cause of liver disease. Treatment with chelating agents is associated with multiple side effects, and colitis should be recognized as a serious adverse drug reaction to trientine. Such a serious adverse event can trigger hepatic decompensation with the need for liver transplantation.