Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2022; 14(7): 1459-1469
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1459
Hepatobiliary phases in magnetic resonance imaging using liver-specific contrast for focal lesions in clinical practice
Daniel Alvarenga Fernandes, Eduardo Andreazza Dal Lago, Felipe Aguera Oliver, Bruna Melo Coelho Loureiro, Daniel Lahan Martins, Thiago José Penachim, Ricardo Hoelz de Oliveira Barros, José de Arimatéia Batista Araújo Filho, Larissa Bastos Eloy da Costa, Áurea Maria Oliveira da Silva, Elaine Cristina de Ataíde, Ilka de Fátima Santana Ferreira Boin, Nelson Marcio Gomes Caserta
Daniel Alvarenga Fernandes, Eduardo Andreazza Dal Lago, Daniel Lahan Martins, Thiago José Penachim, Ricardo Hoelz de Oliveira Barros, Nelson Marcio Gomes Caserta, Department of Radiology, School of Medical Sciences, University of Campinas- UNICAMP, Campinas 13083-888, São Paulo, Brazil
Felipe Aguera Oliver, Department of Radiology, Medical School, São Paulo State University- UNESP, Botucatu 18618-970, São Paulo, Brazil
Bruna Melo Coelho Loureiro, Instituto de Radiologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo- InRad/HC-FMUSP, São Paulo 05403-010, SP, Brazil
José de Arimatéia Batista Araújo Filho, Department of Radiology, Sírio- Libanês Hospital, São Paulo 05652-900, SP, Brazil
Larissa Bastos Eloy da Costa, Department of Pathology, School of Medical Sciences, University of Campinas - UNICAMP, Campinas 13083-888, São Paulo, Brazil
Áurea Maria Oliveira da Silva, Elaine Cristina de Ataíde, Ilka de Fátima Santana Ferreira Boin, Liver Transplant Unit, Department of Surgery, School of Medical Sciences, University of Campinas- UNICAMP, Campinas 13083-888, São Paulo, Brazil
Author contributions: Fernandes DA, Caserta NMG, and Boin IFFS designed the research study; Fernandes DA, Dal Lago EA, Oliver FA, and Loureiro BMC performed the research; Dal Lago EA, Oliver FA, Martins DL, Penachim TJ, Barros RHO, and Araújo-Filho JAB contributed analytic tools and analyzed the data; and All authors have read and approved the final manuscript.
Institutional review board statement: Project approved by the Institutional Research Ethics Committee, UNICAMP, opinion number 962.639, CAAE: 41531415.0.0000.5404. Identification of the study under the Universal Trial Number (UTN): U1111-1247-9655.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: Dataset available from the corresponding author at daniel_alvafer@yahoo.com.br. The presented data are anonymized and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Daniel Alvarenga Fernandes, Doctor, Medical Assistant, Research Associate, Department of Radiology, School of Medical Sciences, University of Campinas- UNICAMP, Rua Vital Brasil, 251, Cidade Universitária, Campinas 13083-888, São Paulo, Brazil. daniel_alvafer@yahoo.com.br
Received: February 23, 2022
Peer-review started: February 23, 2022
First decision: April 17, 2022
Revised: April 20, 2022
Accepted: July 11, 2022
Article in press: July 11, 2022
Published online: July 27, 2022
Processing time: 153 Days and 21.1 Hours
Core Tip

Core Tip: The translational objective was to determine the value of hepatobiliary phases using gadoxetic acid as a liver-specific agent in magnetic resonance imaging (MRI) in the characterization of benign and malignant focal liver lesions (FLL) in clinical practice. Morphofunctional MRI with gadoxetic acid in addition to the usual dynamic phases after contrast medium (arterial, portal and transitional/ equilibrium) increased the proportion of hits for differentiation between benign and malignant FLL in relation to the definitive diagnosis. The results suggest a relevant impact on the definition of strategies for the approach of focal hepatic lesions, as well as in the assessment of the treatment employed.