Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420 [PMID: 36158920 DOI: 10.4254/wjh.v14.i7.1408]
Corresponding Author of This Article
Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 27, 2022; 14(7): 1408-1420 Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1408
Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans
Rafael Torres-Valadez, Sonia Roman, Claudia Ojeda-Granados, Karina Gonzalez-Aldaco, Arturo Panduro
Rafael Torres-Valadez, Sonia Roman, Claudia Ojeda-Granados, Karina Gonzalez-Aldaco, Arturo Panduro, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico
Rafael Torres-Valadez, Unidad Especializada en Investigación, Desarrollo e Innovación en Medicina Genómica Centro Nayarita de Innovación y Transferencia de Tecnología, Universidad Autónoma de Nayarit, Unidad Académica de Salud Integral, Tepic, Nayarit 63173, Mexico
Author contributions: Panduro A conceived and designed the study; Torres-Valadez R, Ojeda-Granados C and Gonzalez-Aldaco K carried out experimentation, and data collection; Panduro A, Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K did analyses and interpretation of data; Torres-Valadez R drafted the manuscript. All authors critically revised the manuscript for intellectual content. All authors revised and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Civil Hospital of Guadalajara, Guadalajara, Jalisco, Mexico.
Informed consent statement: All patients signed a written informed consent before enrollment, and anonymized data was employed to continue the statistical analysis.
Conflict-of-interest statement: All authors have no conflict of interest to disclose.
Data sharing statement: The dataset is available from the corresponding author at apanduro@prodigy.net.mx.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx
Received: January 21, 2022 Peer-review started: January 21, 2022 First decision: June 7, 2022 Revised: June 20, 2022 Accepted: July 6, 2022 Article in press: July 6, 2022 Published online: July 27, 2022 Processing time: 187 Days and 12.3 Hours
Core Tip
Core Tip: Dyslipidemia is a metabolic alteration caused by gene-environmental interactions influenced by ethnicity. Genetic polymorphisms can modify the frequency and outcome of the hyperlipidemic state. Our results showed a differential distribution of gene polymorphisms associated with hypercholesterolemia (APOE4, LDLR), hypertriglyceridemia (APOE2, MTTP), and hypoalphalipoproteinemia (ABCA1) among Native Americans and Mestizo Mexicans of West Mexico. Hypercholesterolemia was the predominant dyslipidemia. In normal weight subjects, the APOB TT and LDLR GG genotypes increased the risk for hypercholesterolemia in the context of the Mestizo ethnicity. Regional personalized-medicine prevention strategies based on the host's genetic and environmental factors are required to decrease the prevalence of dyslipidemias.
