Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2022; 14(6): 1190-1199
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1190
Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma
Kazuto Tajiri, Hiroyuki Ito, Kengo Kawai, Yoshiro Kashii, Yuka Hayashi, Aiko Murayama, Masami Minemura, Terumi Takahara, Yukihiro Shimizu, Ichiro Yasuda
Kazuto Tajiri, Yuka Hayashi, Aiko Murayama, Masami Minemura, Terumi Takahara, Ichiro Yasuda, Department of Gastroenterology, Toyama University Hospital, Toyama 930-0194, Japan
Hiroyuki Ito, Department of Gastroenterology, Takaoka Municipal Hospital, Takaoka 933-8550, Japan
Kengo Kawai, Yukihiro Shimizu, Gastroenterology Center, Nanto Municipal Hospital, Nanto 932-0211, Japan
Yoshiro Kashii, Department of Gastroenterology, Saiseikai Toyama Hospital, Toyama 931-8533, Japan
Author contributions: Tajiri K designed and performed the research and wrote the paper; Ito H, Kawai K, Murayama A, Hayashi Y, Minemura M, Takahara T, and Shimizu Y contributed to the management of patients; Shimizu Y and Yasuda I supervised the work.
Institutional review board statement: This study was reviewed and approved by the ETHICs Committee of Toyama University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient had agreed to treatment with confirmed written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kazuto Tajiri, MD, PhD, Associate Professor, Department of Gastroenterology, Toyama University Hospital, 2630 Sugitani, Toyama 930-0194, Japan. tajikazu@med.u-toyama.ac.jp
Received: January 12, 2022
Peer-review started: January 12, 2022
First decision: March 16, 2022
Revised: March 18, 2022
Accepted: May 28, 2022
Article in press: May 28, 2022
Published online: June 27, 2022
Processing time: 162 Days and 7.2 Hours
Core Tip

Core Tip: To estimate the therapeutic value of direct-acting antivirals (DAAs) in hepatitis C virus (HCV)-infected patients with a history of hepatocellular carcinoma (HCC), the clinical course of HCV patients with or without a history of HCC after DAA therapy was retrospectively analyzed. DAA treatment did not increase the incidence rate of HCC recurrence/occurrence or enhance malignant transformation of HCC in patients with a history of HCC. The risk of HCC recurrence after DAA therapy was significantly associated with the frequency of HCC recurrence/occurrence before DAA therapy.