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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2022; 14(5): 1006-1015
Published online May 27, 2022. doi: 10.4254/wjh.v14.i5.1006
Published online May 27, 2022. doi: 10.4254/wjh.v14.i5.1006
Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults
Zahra Darabi, Sayyed Saeid Khayyatzadeh, Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Zahra Darabi, Hassan Mozaffari-Khosravi, Sayyed Saeid Khayyatzadeh, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Richard James Webb, School of Health Sciences, Liverpool Hope University, Liverpool L16 9JD, United Kingdom
Hassan Mozaffari-Khosravi, Nutrition and Food Security Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, Iran
Masoud Mirzaei, Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Ian Glynn Davies, School of Sports and Exercise Sciences, Faculty of Science, Liverpool John Moores University, IM Marsh Campus, Barkhill Road, Liverpool L17 6AF, United Kingdom
Mohsen Mazidi, Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom
Mohsen Mazidi, Department of Twin Research & Genetic Epidemiology, King’s college London, South Wing St Thomas', London SE1 7EH, United Kingdom
Author contributions: Darabi Z, Mozaffari-Khosravi H, Mirzaei M, Khayyatzadeh SS, and Mazidi M conceived and designed the study, acquired and analysed the data; Darabi Z and Webb RJ interpreted the data and wrote the first draft of the manuscript; All authors critically revised the manuscript.
Institutional review board statement: The study was also approved by the ethics committee of Shahid Sadoughi University of Medical Sciences (approval code: IR.SSU.SPH.REC.1397.161).
Informed consent statement: All involved persons gave their informed consent prior to study inclusion.
Conflict-of-interest statement: The authors know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at mohsen.mazidi@ndph.ox.ac.uk.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohsen Mazidi, PhD, Research Scientist, Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Headington, Oxford OX3 7LF, United Kingdom. mohsen.mazidi@ndph.ox.ac.uk
Received: November 6, 2021
Peer-review started: November 6, 2021
First decision: December 27, 2021
Revised: January 28, 2022
Accepted: May 7, 2022
Article in press: May 7, 2022
Published online: May 27, 2022
Processing time: 199 Days and 4.2 Hours
Peer-review started: November 6, 2021
First decision: December 27, 2021
Revised: January 28, 2022
Accepted: May 7, 2022
Article in press: May 7, 2022
Published online: May 27, 2022
Processing time: 199 Days and 4.2 Hours
Core Tip
Core Tip: It has been debated whether phytochemicals are hepatoprotective. Furthermore, to the authors knowledge, this has not previously been researched in an Iranian population. In our study we used a dietary phytochemical index to categorise participants in terms of their intake of dietary phytochemicals. We found that participants with higher intakes of phytochemicals had a healthier overall dietary pattern and lower levels of alanine aminotransferase, which may be suggestive of improved liver function. Despite this, several metabolic disturbances were also revealed in these participants.