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World J Hepatol. Apr 27, 2022; 14(4): 708-718
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.708
Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity
Rajesh Kumar
Rajesh Kumar, Department of School Education, Haryana Government, Panchkula 134109, Haryana, India
Author contributions: Kumar R wrote, edit the paper and proofread the paper.
Conflict-of-interest statement: There is no conflict of interest among authors.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Rajesh Kumar, Lecturer, Department of School Education, Haryana Government, Karsa Dod, Karnal, Panchkula 134109, Haryana, India.
Received: July 14, 2021
Peer-review started: July 14, 2021
First decision: August 18, 2021
Revised: September 4, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: April 27, 2022
Core Tip

Core Tip: Worldwide, 350 million people are chronically infected with hepatitis B virus and are at risk for cirrhosis and hepatocellular carcinoma. Both core promoter and precore mutations help rescue the virus from host immune surveillance and result in the formation of mutated strains that may have altered pathogenicity. Precore/core promoter (preC/C) mutations are associated with advanced liver disease. We discuss mainly preC/C mutations and their correlation with genotypes and liver disease severity.