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World J Hepatol. Mar 27, 2022; 14(3): 495-503
Published online Mar 27, 2022. doi: 10.4254/wjh.v14.i3.495
Small duct primary sclerosing cholangitis: A discrete variant or a bridge to large duct disease, a practical review
Christopher M Nguyen, Kevin T Kline, Heather L Stevenson, Kashif Khan, Sreeram Parupudi
Christopher M Nguyen, Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, United States
Kevin T Kline, Kashif Khan, Sreeram Parupudi, Department of Gastroenterology and Hepatology, The University of Texas Medical Branch, Galveston, TX 77555, United States
Heather L Stevenson, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, United States
Author contributions: Nguyen CM and Kline KT contributed to the draft and conception; Kline KT and Stevenson HL revised the manuscript; Stevenson HL provided original pathology images; Khan K and Parupudi S contributed to conception, revision and final approval.
Conflict-of-interest statement: The authors report no conflicts of interest or financial disclosures relevant to the manuscript nor any funding of financial support received.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christopher M Nguyen, DO, Doctor, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, John Sealy Annex Room 4.108, Galveston, TX 77555, United States. chmnguye@utmb.edu
Received: February 26, 2021
Peer-review started: February 26, 2021
First decision: May 3, 2021
Revised: May 12, 2021
Accepted: February 15, 2022
Article in press: February 15, 2022
Published online: March 27, 2022
Processing time: 391 Days and 9.6 Hours
Core Tip

Core Tip: Strong associations between small duct primary sclerosing cholangitis (sdPSC) and inflammatory bowel disease (IBD) have been established with suspicion that concurrent sdPSC-IBD may be a key prognostic factor in determining which patients are at risk of progression to ldPSC.