Retrospective Cohort Study
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World J Hepatol. Oct 27, 2022; 14(10): 1907-1919
Published online Oct 27, 2022. doi: 10.4254/wjh.v14.i10.1907
Hepatic involvement in children with acute bronchiolitis
Hasan M Isa, Asma Z Hasan, Sara I Khalifa, Sana S Alhewaizem, Abdulrahman D Mahroofi, Fatema N Alkhan, Mohammed Al-Beltagi
Hasan M Isa, Sara I Khalifa, Fatema N Alkhan, Department of Pediatrics, Salmaniya Medical Complex, Manama 12, Bahrain
Hasan M Isa, Department of Pediatrics, Arabian Gulf University, Manama 26671, Bahrain
Asma Z Hasan, Department of Pediatrics, Sulwan Psychiatric Hospital, Manama 973, Bu Quwah, Bahrain
Sana S Alhewaizem, Department of Pediatrics, Dream Reem Medical Center, Muharraq 50573, Bahrain
Abdulrahman D Mahroofi, Department of Pediatrics, King Hamad University Hospital, Muharraq 24343, Bahrain
Mohammed Al-Beltagi, Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31527, Algharbia, Egypt
Mohammed Al-Beltagi, Department of Pediatrics, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain
Mohammed Al-Beltagi, Department of Pediatrics, University Medical Center, Dr. Sulaiman Al-Habib Medical Group, Bahrain, Manama 26671, Bahrain
Author contributions: Isa HM, Hasan AZ, Khalifa SI, Alhewaizem SS, Mahroofi AD, Alkhan FN, and Al-Beltagi M collected the data and wrote and revised the manuscript.
Institutional review board statement: The study was ethically approved by the Research and Research Ethics Committee for Governmental Hospitals, Salmaniya Medical Complex, Bahrain (Approval No. 27130220).
Informed consent statement: Consent was not needed as the study was retrospective without exposure of the patient's data.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Data sharing statement: Data are available upon reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mohammed Al-Beltagi, MBChB, MD, MSc, PhD, Chairman, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, AlBahr Street, Tanta 31527, Algharbia, Egypt.
Received: June 14, 2022
Peer-review started: June 14, 2022
First decision: August 18, 2022
Revised: August 22, 2022
Accepted: October 10, 2022
Article in press: October 10, 2022
Published online: October 27, 2022
Core Tip

Core Tip: How frequent is hepatic involvement in children with acute bronchiolitis? Furthermore, what are the predicted factors? To answer these questions, we conducted this retrospective study. Despite the low prevalence of impaired liver function in patients with acute bronchiolitis and the benign course, there was a rising trend in alanine aminotransferase levels during follow-up. Elevated liver enzymes were linked to an extended hospital stay and positive urine cultures. Therefore, children with acute bronchiolitis should be monitored and followed up with liver function tests.