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World J Hepatol. Aug 27, 2021; 13(8): 904-915
Published online Aug 27, 2021. doi: 10.4254/wjh.v13.i8.904
Therapeutic plasma exchange in liver failure
Abimbola Chris-Olaiya, Aanchal Kapoor, Kristin S Ricci, Christina C Lindenmeyer
Abimbola Chris-Olaiya, Aanchal Kapoor, Department of Critical Care, Cleveland Clinic, Cleveland, OH 44195, United States
Kristin S Ricci, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH 44195, United States
Christina C Lindenmeyer, Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Chris-Olaiya A designed the outline and drafted the article; Ricci K made critical revisions related to intellectual content and approved the final version; Kapoor A provided input in the writing and made critical revisions; Lindenmeyer C coordinated the writing of the paper, made critical revisions, and approved the final version.
Conflict-of-interest statement: The authors have none to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christina C Lindenmeyer, MD, Assistant Professor, Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, 9500 Euclid Avenue A51, Cleveland, OH 44195, United States. lindenc@ccf.org
Received: March 7, 2021
Peer-review started: March 7, 2021
First decision: March 29, 2021
Revised: April 2, 2021
Accepted: July 20, 2021
Article in press: July 20, 2021
Published online: August 27, 2021
Processing time: 165 Days and 16.7 Hours
Core Tip

Core Tip: Multi-organ failure accompanying liver failure is mediated by overwhelming systemic inflammation and altered host immunity. Therapeutic plasma exchange has been proven to be an efficacious therapy in autoimmune conditions and altered immunity. We review the efficacy and technical considerations of therapeutic plasma exchange in both acute and acute-on-chronic liver failure.