Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2021; 13(7): 804-814
Published online Jul 27, 2021. doi: 10.4254/wjh.v13.i7.804
Safety of liver resection in patients receiving antithrombotic therapy: A systematic review of the literature
Takahisa Fujikawa
Takahisa Fujikawa, Department of Surgery, Kokura Memorial Hospital, Fukuoka 802-8555, Japan
Author contributions: Fujikawa T designed and performed research, and analyzed data; Fujikawa T prepared a manuscript and reviewed it.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Data sharing statement: No additional data are available.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Takahisa Fujikawa, FACS, MD, PhD, Chief Doctor, Department of Surgery, Kokura Memorial Hospital, 3-2-1 Asano, Kitakyushu, Fukuoka 802-8555, Japan.
Received: March 5, 2021
Peer-review started: March 5, 2021
First decision: May 2, 2021
Revised: May 7, 2021
Accepted: July 2, 2021
Article in press: July 2, 2021
Published online: July 27, 2021
Core Tip

Core Tip: A total of 16 published articles on antithrombotic therapy and hepatectomy have been reviewed systematically. The articles showed that the risk of thromboembolic and/or bleeding events in patients with continued preoperative aspirin was not different from those in patients with no antithrombotic or interrupted antiplatelet drugs, although pharmacological prophylaxis of venous thromboembolism is still controversial, especially when performing hepatectomy in Asian patient populations.