Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2021; 13(6): 709-716
Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.709
Distant metastasis of hepatocellular carcinoma to Meckel’s cave and cranial nerves: A case report and review of literature
Soo Ki Kim, Takako Fujii, Ryouhei Komaki, Hisato Kobayashi, Toyokazu Okuda, Yumi Fujii, Takanobu Hayakumo, Kanako Yuasa, Masahiro Takami, Aya Ohtani, Yuka Saijo, Yu-Ichiro Koma, Soo Ryang Kim
Soo Ki Kim, Takako Fujii, Toyokazu Okuda, Yumi Fujii, Takanobu Hayakumo, Kanako Yuasa, Masahiro Takami, Soo Ryang Kim, Department of Gastroenterology, Kobe Asahi Hospital, Kobe 653-0801, Hyogo, Japan
Ryouhei Komaki, Division of Neurology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan
Hisato Kobayashi, Department of Radiology, Kobe Asahi Hospital, Kobe 653-0801, Hyogo, Japan
Aya Ohtani, Yuka Saijo, Department of Pharmacy, Kobe Asahi Hospital, Kobe 653-0801, Hyogo, Japan
Yu-Ichiro Koma, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan
Author contributions: Kim SK conceived the case and wrote the manuscript; Kim SR and Komaki R observed the clinical course of the patient and made the figures; Fujii T, Okuda T, Fujii Y, Hayakumo T, Yuasa K, Takami M, Ohtani A and Saijo Y observed the clinical course of the patient; Kobayashi H conducted the radiological examinations and interpreted the imaging findings; Koma YI conducted histological examinations.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takako Fujii, MD, PhD, Doctor, Department of Gastroenterology, Kobe Asahi Hospital, 3-5-25 Bououji-cho, Nagata-ku, Kobe 653-0801, Hyogo, Japan. kytacako@gmail.com
Received: February 17, 2021
Peer-review started: February 17, 2021
First decision: March 16, 2021
Revised: March 29, 2021
Accepted: June 16, 2021
Article in press: June 16, 2021
Published online: June 27, 2021
Processing time: 125 Days and 21.9 Hours
Core Tip

Core Tip: We describe a case of hyperalgesia of the right side of the face and limited abduction of the right eye caused by hepatocellular carcinoma (HCC) metastasizing to the right cavernous sinus, the right Meckel’s cave, and the right petrous bone diagnosed through neurological findings and imaging studies. Although HCC metastasizing to the cavernous sinus, Meckel’s cave and the petrous bone is rare, clinicians need to be vigilant when the patients show neurological dysfunction, especially cranial nerve involvement.